Gtpbp8 GTP-binding protein 8 (putative) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtpbp8provided by MGI
Official Full Name: GTP-binding protein 8 (putative)provided by MGI
Primary source: MGI:MGI:1913317
See related: Ensembl:ENSMUSG00000022668 AllianceGenome:MGI:1913317
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610037H22Rik
Summary: Predicted to enable GTP binding activity and metal ion binding activity. Located in mitochondrion. Orthologous to human GTPBP8 (GTP binding protein 8 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 6.8), CNS E18 (RPKM 6.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16; 16 B4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (44559242..44566726, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (44738879..44746363, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Gtpbp8 gene: The Gtpbp8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 497 organisms have orthologs with human gene Gtpbp8
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GTP-binding protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159329.1 → NP_001152801.1 GTP-binding protein 8 isoform 2

See identical proteins and their annotated locations for NP_001152801.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

BC107217, BE197762, CJ169587

Consensus CDS

CCDS49855.1

UniProtKB/Swiss-Prot

Q9CY28

Related

ENSMUSP00000023348.5, ENSMUST00000023348.11

Conserved Domains (2) summary

cd01876
Location:47 → 214

YihA_EngB; YihA (EngB) GTPase family

TIGR00231
Location:46 → 203

small_GTP; small GTP-binding protein domain
NM_001356392.1 → NP_001343321.1 GTP-binding protein 8 isoform 3

Status: VALIDATED

Source sequence(s)

AC122217

Related

ENSMUSP00000123974.2, ENSMUST00000161436.2

Conserved Domains (1) summary

cd01876
Location:114 → 248

YihA_EngB; YihA (EngB) GTPase family
NM_025332.3 → NP_079608.1 GTP-binding protein 8 isoform 1

See identical proteins and their annotated locations for NP_079608.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK147840, BE197762, CJ169587

Consensus CDS

CCDS28188.1

UniProtKB/Swiss-Prot

Q3KNM0, Q9CY28

Related

ENSMUSP00000125352.2, ENSMUST00000162512.8

Conserved Domains (2) summary

cd01876
Location:113 → 281

YihA_EngB; YihA (EngB) GTPase family

pfam00009
Location:114 → 273

GTP_EFTU; Elongation factor Tu GTP binding domain