U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cndp2 CNDP dipeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 66054, updated on 12-May-2024

Summary

Official Symbol
Cndp2provided by MGI
Official Full Name
CNDP dipeptidase 2provided by MGI
Primary source
MGI:MGI:1913304
See related
Ensembl:ENSMUSG00000024644 AllianceGenome:MGI:1913304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cn2; Pep1; Dip-2; Pep-1; 0610010E05Rik
Summary
Enables dipeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including 1st branchial arch; ear; limb; nervous system; and urinary system. Orthologous to human CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 201.3), placenta adult (RPKM 117.9) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cndp2 in Genome Data Viewer
Location:
18 E4; 18 57.53 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84685590..84703827, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84667465..84685702, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene carnosine dipeptidase 1 Neighboring gene STARR-seq mESC enhancer starr_45251 Neighboring gene STARR-seq mESC enhancer starr_45252 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45253 Neighboring gene STARR-positive B cell enhancer ABC_E1964 Neighboring gene STARR-seq mESC enhancer starr_45255 Neighboring gene WD repeat domain 53 pseudogene Neighboring gene divergent protein kinase domain 1C Neighboring gene predicted gene, 25005

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alanylglutamate dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytosolic non-specific dipeptidase
Names
CNDP dipeptidase 2 (metallopeptidase M20 family)
cytosolic nonspecific dipeptidase
glutamate carboxypeptidase-like protein 1
peptidase 1
peptidase A
threonyl dipeptidase
NP_001276460.1
NP_075638.2
XP_030106430.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289531.1NP_001276460.1  cytosolic non-specific dipeptidase

    See identical proteins and their annotated locations for NP_001276460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein
    Source sequence(s)
    AK003779, AK152442, CJ306472, CN721222
    Consensus CDS
    CCDS29383.1
    UniProtKB/Swiss-Prot
    Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
    UniProtKB/TrEMBL
    Q6KAT3
    Related
    ENSMUSP00000128696.2, ENSMUST00000168419.3
    Conserved Domains (1) summary
    cd05676
    Location:7473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
  2. NM_023149.3NP_075638.2  cytosolic non-specific dipeptidase

    See identical proteins and their annotated locations for NP_075638.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003779, CJ078789, CJ306472
    Consensus CDS
    CCDS29383.1
    UniProtKB/Swiss-Prot
    Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
    UniProtKB/TrEMBL
    Q6KAT3
    Related
    ENSMUSP00000025546.10, ENSMUST00000025546.17
    Conserved Domains (1) summary
    cd05676
    Location:7473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84685590..84703827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250570.2XP_030106430.1  cytosolic non-specific dipeptidase isoform X1

    UniProtKB/Swiss-Prot
    Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
    UniProtKB/TrEMBL
    Q6KAT3
    Conserved Domains (1) summary
    cd05676
    Location:7473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase