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Drp2 dystrophin related protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 66027, updated on 13-Aug-2019

Summary

Official Symbol
Drp2provided by RGD
Official Full Name
dystrophin related protein 2provided by RGD
Primary source
RGD:621750
See related
Ensembl:ENSRNOG00000026704
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DRP-2
Expression
Biased expression in Brain (RPKM 70.7), Adrenal (RPKM 36.7) and 5 other tissues See more
Orthologs

Genomic context

See Drp2 in Genome Data Viewer
Location:
Xq32
Exon count:
26
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105239623..105290233)
106 current Rn_Celera (GCF_000002265.2) X AC_000089.1 (98649223..98695429)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (105130982..105180671)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 35A Neighboring gene centromere protein I Neighboring gene TATA-box binding protein associated factor 7-like Neighboring gene translocase of inner mitochondrial membrane 8A1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dystrophin-related protein 2
Names
dystrophin-related protein 2 A-form

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023971.1NP_076461.1  dystrophin-related protein 2

    See identical proteins and their annotated locations for NP_076461.1

    Status: PROVISIONAL

    Source sequence(s)
    AF195787
    UniProtKB/Swiss-Prot
    Q9EPA0
    Related
    ENSRNOP00000037371.3, ENSRNOT00000039864.3
    Conserved Domains (5) summary
    cd00176
    Location:111339
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:357385
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:608656
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:386504
    EF-hand_2; EF hand
    pfam09069
    Location:508599
    EF-hand_3; EF-hand

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    105239623..105290233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773433.2XP_008771655.1  dystrophin-related protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008771655.1

    UniProtKB/Swiss-Prot
    Q9EPA0
    Related
    ENSRNOP00000070220.1, ENSRNOT00000085693.1
    Conserved Domains (5) summary
    cd00176
    Location:111339
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:357385
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:608656
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:386504
    EF-hand_2; EF hand
    pfam09069
    Location:508599
    EF-hand_3; EF-hand
  2. XM_008773435.2XP_008771657.1  dystrophin-related protein 2 isoform X2

    Conserved Domains (5) summary
    cd00176
    Location:111339
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:357385
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:608656
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:386504
    EF-hand_2; EF hand
    pfam09069
    Location:508599
    EF-hand_3; EF-hand
  3. XM_008773436.2XP_008771658.1  dystrophin-related protein 2 isoform X3

    Conserved Domains (5) summary
    cd00176
    Location:33261
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:279307
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:530578
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:308426
    EF-hand_2; EF hand
    pfam09069
    Location:430521
    EF-hand_3; EF-hand

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    98649223..98695429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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