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CHID1 chitinase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 66005, updated on 13-Mar-2020

Summary

Official Symbol
CHID1provided by HGNC
Official Full Name
chitinase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:28474
See related
Ensembl:ENSG00000177830 MIM:615692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GL008; SICLP; SI-CLP
Expression
Ubiquitous expression in testis (RPKM 12.9), spleen (RPKM 11.8) and 25 other tissues See more
Orthologs

Genomic context

See CHID1 in Genome Data Viewer
Location:
11p15.5
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (867859..915058, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (867859..915058, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene tetraspanin 4 Neighboring gene adaptor related protein complex 2 subunit alpha 2 Neighboring gene RNA, U6 small nuclear 1025, pseudogene Neighboring gene mucin 6, oligomeric mucus/gel-forming

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with CHID1; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3234, FLJ42707

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chitin binding IEA
Inferred from Electronic Annotation
more info
 
oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharide binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal lumen TAS
Traceable Author Statement
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleus HDA PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chitinase domain-containing protein 1
Names
stabilin-1 interacting chitinase-like protein
NP_001136146.1
NP_001136147.1
NP_001136148.1
NP_001136149.1
NP_076436.3
XP_005253129.1
XP_005253130.1
XP_006718345.1
XP_011518601.1
XP_011518602.1
XP_011518603.1
XP_011518604.1
XP_016873655.1
XP_016873656.1
XP_016873657.1
XP_024304431.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142674.2NP_001136146.1  chitinase domain-containing protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001136146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode isoform a.
    Source sequence(s)
    AP006623, BC000001, BI818660, CK904484
    Consensus CDS
    CCDS7722.1
    UniProtKB/Swiss-Prot
    Q9BWS9
    Related
    ENSP00000388156.2, ENST00000436108.6
    Conserved Domains (1) summary
    cd02876
    Location:77393
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
  2. NM_001142675.1NP_001136147.1  chitinase domain-containing protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001136147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode isoform a.
    Source sequence(s)
    AP006623, BC095409, BI759317, BI821281, CK904484, DA983719
    Consensus CDS
    CCDS7722.1
    UniProtKB/Swiss-Prot
    Q9BWS9
    Related
    ENSP00000391255.1, ENST00000449825.5
    Conserved Domains (1) summary
    cd02876
    Location:77393
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
  3. NM_001142676.2NP_001136148.1  chitinase domain-containing protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001136148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (b) has the same N- and C-termini but includes an additional segment, compared to isoform a.
    Source sequence(s)
    AK075413, AP006623, CK904484
    Consensus CDS
    CCDS44511.1
    UniProtKB/Swiss-Prot
    Q9BWS9
    Related
    ENSP00000435503.1, ENST00000528581.5
    Conserved Domains (2) summary
    cd02876
    Location:102418
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    smart00636
    Location:106409
    Glyco_18; Glyco_18 domain
  4. NM_001142677.2NP_001136149.1  chitinase domain-containing protein 1 isoform c precursor

    See identical proteins and their annotated locations for NP_001136149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter than isoform a.
    Source sequence(s)
    AP006623, AY037151, CK904484
    Consensus CDS
    CCDS44510.1
    UniProtKB/Swiss-Prot
    Q9BWS9
    Related
    ENSP00000416034.2, ENST00000429789.6
    Conserved Domains (2) summary
    cd02876
    Location:77362
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    smart00636
    Location:81353
    Glyco_18; Glyco_18 domain
  5. NM_023947.4NP_076436.3  chitinase domain-containing protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_076436.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode isoform a.
    Source sequence(s)
    AP006623, BC095409, CK904484
    Consensus CDS
    CCDS7722.1
    UniProtKB/Swiss-Prot
    Q9BWS9
    Related
    ENSP00000325055.8, ENST00000323578.13
    Conserved Domains (1) summary
    cd02876
    Location:77393
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    867859..915058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718282.2XP_006718345.1  chitinase domain-containing protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006718345.1

    UniProtKB/Swiss-Prot
    Q9BWS9
    Conserved Domains (1) summary
    cd02876
    Location:77393
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
  2. XM_005253072.2XP_005253129.1  chitinase domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    cd02876
    Location:107423
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    smart00636
    Location:111414
    Glyco_18; Glyco_18 domain
  3. XM_011520300.2XP_011518602.1  chitinase domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd02876
    Location:162447
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    smart00636
    Location:166438
    Glyco_18; Glyco_18 domain
  4. XM_011520299.2XP_011518601.1  chitinase domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd02876
    Location:162478
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    smart00636
    Location:166469
    Glyco_18; Glyco_18 domain
  5. XM_005253073.4XP_005253130.1  chitinase domain-containing protein 1 isoform X7

    See identical proteins and their annotated locations for XP_005253130.1

    UniProtKB/Swiss-Prot
    Q9BWS9
    Conserved Domains (2) summary
    cd02876
    Location:77362
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    smart00636
    Location:81353
    Glyco_18; Glyco_18 domain
  6. XM_017018166.1XP_016873655.1  chitinase domain-containing protein 1 isoform X6

    UniProtKB/Swiss-Prot
    Q9BWS9
    Conserved Domains (1) summary
    cd02876
    Location:77393
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
  7. XM_011520301.3XP_011518603.1  chitinase domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    cd02876
    Location:162405
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    smart00636
    Location:166397
    Glyco_18; Glyco_18 domain
  8. XM_024448663.1XP_024304431.1  chitinase domain-containing protein 1 isoform X8

    Conserved Domains (1) summary
    cd02876
    Location:77320
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
  9. XM_011520302.3XP_011518604.1  chitinase domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    cd02876
    Location:162404
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    smart00636
    Location:166397
    Glyco_18; Glyco_18 domain
  10. XM_017018168.1XP_016873657.1  chitinase domain-containing protein 1 isoform X9

  11. XM_017018167.2XP_016873656.1  chitinase domain-containing protein 1 isoform X9

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