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ZFTA zinc finger translocation associated [ Homo sapiens (human) ]

Gene ID: 65998, updated on 9-Sep-2025
Official Symbol
ZFTAprovided by HGNC
Official Full Name
zinc finger translocation associatedprovided by HGNC
Primary source
HGNC:HGNC:28449
See related
Ensembl:ENSG00000188070 MIM:615699; AllianceGenome:HGNC:28449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf95
Summary
Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in ovary (RPKM 10.0), endometrium (RPKM 8.7) and 25 other tissues See more
Orthologs
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See ZFTA in Genome Data Viewer
Location:
11q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63759892..63768775, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63749259..63758142, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63527364..63536247, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:63398741-63399940 Neighboring gene lncRNA regulator of PLAAT3 mediated phospholipid metabolism Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438213-63438714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438715-63439214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3441 Neighboring gene reticulon 3 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:63529087-63529846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3445 Neighboring gene RNA, 7SL, cytoplasmic 596, pseudogene Neighboring gene Sharpr-MPRA regulatory region 949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3446 Neighboring gene spindlin interactor and repressor of chromatin binding

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Ependymoma-like tumor with mesenchymal differentiation (ELTMD) with ZFTA:NCOA1 fusion: A diagnostic challenge. Dorwal P, et al. Neuropathology, 2024 Jun. PMID 37931917
  2. C11orf95-RELA fusion present in a primary intracranial extra-axial ependymoma: Report of a case with literature review. Nambirajan A, et al. Neuropathology, 2016 Oct. PMID 27121356
  3. Biology and management of ependymomas. Wu J, et al. Neuro Oncol, 2016 Jul. PMID 27022130, Free PMC Article
  4. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. Parker M, et al. Nature, 2014 Feb 27. PMID 24553141, Free PMC Article
  5. Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors. Nishio J. J Biomed Biotechnol, 2011. PMID 21274402, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.
    Title: CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.
  2. Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
    Title: Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
  3. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
    Title: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
  4. Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features.
    Title: Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features.
  5. C11orf95-RELA fusion transcript is thought to be the driver genetic alteration leading to activation of the NFkB pathway in supratentorial ependymomas.
    Title: C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma.
  6. C11orf95-RELA fusions represent a unique novel mechanism leading to pathological activation of NF-kappaB signaling in supratentorial ependymomas.
    Title: Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway.
  7. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas.
    Title: Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Markers

Homology

Clone Names

  • MGC3032

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger translocation-associated protein
Names
uncharacterized protein C11orf95

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144936.2 → NP_001138408.1  zinc finger translocation-associated protein

    See identical proteins and their annotated locations for NP_001138408.1

    Status: VALIDATED

    Source sequence(s)
    AP006289
    Consensus CDS
    CCDS44636.1
    UniProtKB/Swiss-Prot
    A6NLS7, C9JLR9, Q3C1V4
    Related
    ENSP00000482180.1, ENST00000433688.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63759892..63768775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448662.2 → XP_024304430.1  zinc finger translocation-associated protein isoform X3

  2. XM_047427477.1 → XP_047283433.1  zinc finger translocation-associated protein isoform X1

    Related
    ENSP00000618089.1, ENST00000948030.1

  3. XM_047427478.1 → XP_047283434.1  zinc finger translocation-associated protein isoform X2

    Related
    ENSP00000588536.1, ENST00000918477.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63749259..63758142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369723.1 → XP_054225698.1  zinc finger translocation-associated protein isoform X3

  2. XM_054369721.1 → XP_054225696.1  zinc finger translocation-associated protein isoform X1

  3. XM_054369722.1 → XP_054225697.1  zinc finger translocation-associated protein isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023941.1: Suppressed sequence

    Description
    NM_023941.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C9JLR9.1 GenPept UniProtKB/Swiss-Prot:C9JLR9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials