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MRPS34 mitochondrial ribosomal protein S34 [ Homo sapiens (human) ]

Gene ID: 65993, updated on 4-Oct-2020

Summary

Official Symbol
MRPS34provided by HGNC
Official Full Name
mitochondrial ribosomal protein S34provided by HGNC
Primary source
HGNC:HGNC:16618
See related
Ensembl:ENSG00000074071 MIM:611994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRPS12; COXPD32; MRP-S12; MRP-S34
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in kidney (RPKM 21.5), colon (RPKM 19.8) and 25 other tissues See more
Orthologs

Genomic context

See MRPS34 in Genome Data Viewer
Location:
16p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1771895..1773134, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1821891..1823152, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene microRNA 3177 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene nucleotide binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2616

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
28S ribosomal protein S34, mitochondrial
Names
S34mt
mitochondrial 28S ribosomal protein S34
mitochondrial small ribosomal subunit protein mS34

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300900.2NP_001287829.1  28S ribosomal protein S34, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001287829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC012180, AV709743, BC001182
    Consensus CDS
    CCDS73805.1
    UniProtKB/Swiss-Prot
    P82930
    UniProtKB/TrEMBL
    C9JJ19
    Related
    ENSP00000177742.3, ENST00000177742.7
    Conserved Domains (1) summary
    pfam16053
    Location:74194
    MRP-S34; Mitochondrial 28S ribosomal protein S34
  2. NM_023936.2NP_076425.1  28S ribosomal protein S34, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_076425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC001182
    Consensus CDS
    CCDS10444.1
    UniProtKB/Swiss-Prot
    P82930
    Related
    ENSP00000380531.2, ENST00000397375.6
    Conserved Domains (1) summary
    pfam16053
    Location:74187
    MRP-S34; Mitochondrial 28S ribosomal protein S34

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1771895..1773134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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