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ANTKMT adenine nucleotide translocase lysine methyltransferase [ Homo sapiens (human) ]

Gene ID: 65990, updated on 21-Mar-2020

Summary

Official Symbol
ANTKMTprovided by HGNC
Official Full Name
adenine nucleotide translocase lysine methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:14152
See related
Ensembl:ENSG00000103254 MIM:618566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANT-KMT; FAM173A; C16orf24
Expression
Broad expression in kidney (RPKM 5.7), colon (RPKM 4.4) and 22 other tissues See more
Orthologs

Genomic context

See ANTKMT in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (720581..722590)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (770581..772655)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 16 Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene coiled-coil domain containing 78 Neighboring gene hydroxyacylglutathione hydrolase like Neighboring gene cytosolic iron-sulfur assembly component 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC2494

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
peptidyl-lysine trimethylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenine nucleotide translocase lysine N-methyltransferase
Names
family with sequence similarity 173 member A
protein FAM173A
protein N-lysine methyltransferase FAM173A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271285.2NP_001258214.1  adenine nucleotide translocase lysine N-methyltransferase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AI492179, BI597021, BI838160
    Consensus CDS
    CCDS59254.1
    UniProtKB/TrEMBL
    J3KMW5
    Related
    ENSP00000219535.3, ENST00000219535.7
    Conserved Domains (1) summary
    pfam12847
    Location:76143
    Methyltransf_18; Methyltransferase domain
  2. NM_023933.3NP_076422.1  adenine nucleotide translocase lysine N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_076422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AI492179, BC002624, BI597021
    Consensus CDS
    CCDS10423.1
    UniProtKB/Swiss-Prot
    Q9BQD7
    Related
    ENSP00000454380.1, ENST00000569529.6
    Conserved Domains (1) summary
    cl28093
    Location:65123
    HemK; Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    720581..722590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_243298.4 RNA Sequence

    Related
    ENST00000566525.5
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