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DLK2 delta like non-canonical Notch ligand 2 [ Homo sapiens (human) ]

Gene ID: 65989, updated on 13-Mar-2020

Summary

Official Symbol
DLK2provided by HGNC
Official Full Name
delta like non-canonical Notch ligand 2provided by HGNC
Primary source
HGNC:HGNC:21113
See related
Ensembl:ENSG00000171462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLK-2; EGFL9
Expression
Broad expression in skin (RPKM 1.9), prostate (RPKM 1.6) and 23 other tissues See more
Orthologs

Genomic context

See DLK2 in Genome Data Viewer
Location:
6p21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43450352..43456632, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43418090..43423786, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375065 Neighboring gene ATP binding cassette subfamily C member 10 Neighboring gene microRNA 6780b Neighboring gene uncharacterized LOC107986597 Neighboring gene RNA, U6 small nuclear 1113, pseudogene Neighboring gene tight junction associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2487, MGC111055

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein delta homolog 2
Names
EGF-like protein 9
EGF-like-domain, multiple 9
delta-like 2 homolog
epidermal growth factor-like protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286655.1NP_001273584.1  protein delta homolog 2 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the central coding region, compared to variant 2. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AK055380, BC110320, DA332624
    UniProtKB/Swiss-Prot
    Q6UY11
    Conserved Domains (1) summary
    cd00054
    Location:137173
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. NM_001286656.2NP_001273585.1  protein delta homolog 2 isoform c precursor

    See identical proteins and their annotated locations for NP_001273585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the central coding region, compared to variant 2. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    BC110320, BM811564
    Consensus CDS
    CCDS75461.1
    UniProtKB/Swiss-Prot
    Q6UY11
    UniProtKB/TrEMBL
    Q5T3T9
    Related
    ENSP00000361563.1, ENST00000372485.5
    Conserved Domains (1) summary
    cd00054
    Location:168204
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  3. NM_023932.4NP_076421.2  protein delta homolog 2 isoform a precursor

    See identical proteins and their annotated locations for NP_076421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC110320
    Consensus CDS
    CCDS4897.1
    UniProtKB/Swiss-Prot
    Q6UY11
    UniProtKB/TrEMBL
    A0A024RD55
    Related
    ENSP00000361566.3, ENST00000372488.8
    Conserved Domains (1) summary
    cd00054
    Location:174210
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  4. NM_206539.2NP_996262.1  protein delta homolog 2 isoform a precursor

    See identical proteins and their annotated locations for NP_996262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK055380, AY358126
    Consensus CDS
    CCDS4897.1
    UniProtKB/Swiss-Prot
    Q6UY11
    UniProtKB/TrEMBL
    A0A024RD55
    Related
    ENSP00000349893.3, ENST00000357338.3
    Conserved Domains (1) summary
    cd00054
    Location:174210
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43450352..43456632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249308.5XP_005249365.1  protein delta homolog 2 isoform X1

    Conserved Domains (1) summary
    cd00054
    Location:267303
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_011514823.3XP_011513125.1  protein delta homolog 2 isoform X2

    Conserved Domains (1) summary
    cd00054
    Location:236272
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
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