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ZNF747 zinc finger protein 747 [ Homo sapiens (human) ]

Gene ID: 65988, updated on 13-Mar-2020

Summary

Official Symbol
ZNF747provided by HGNC
Official Full Name
zinc finger protein 747provided by HGNC
Primary source
HGNC:HGNC:28350
See related
Ensembl:ENSG00000169955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in prostate (RPKM 3.6), kidney (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF747 in Genome Data Viewer
Location:
16p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30530367..30534970, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30541688..30546345, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha L Neighboring gene RNA, U7 small nuclear 61 pseudogene Neighboring gene microRNA 4518 Neighboring gene zinc finger protein 768 Neighboring gene Sharpr-MPRA regulatory region 7881 Neighboring gene uncharacterized LOC107984875 Neighboring gene ribosomal protein L7 like 1 pseudogene Neighboring gene zinc finger protein 764

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 747 (ZNF747) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2474

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
KRAB domain-containing protein ZNF747

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305018.1NP_001291947.1  KRAB domain-containing protein ZNF747 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA316824, BC001361, BE327668, BM461939, BP359683, CA429734, DC305764
    UniProtKB/Swiss-Prot
    Q9BV97
    Conserved Domains (5) summary
    smart00349
    Location:3796
    KRAB; krueppel associated box
    COG5048
    Location:236273
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:252275
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001305019.1NP_001291948.1  KRAB domain-containing protein ZNF747 isoform 2

    See identical proteins and their annotated locations for NP_001291948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AA316824, AK316254, BC001361, BE327668, BM461939, BP359683, CA429734
    Consensus CDS
    CCDS76856.1
    UniProtKB/Swiss-Prot
    Q9BV97
    UniProtKB/TrEMBL
    B7Z5R0, B7ZAD9
    Related
    ENSP00000457274.1, ENST00000568028.1
    Conserved Domains (5) summary
    smart00349
    Location:3796
    KRAB; krueppel associated box
    COG5048
    Location:235272
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:211231
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:251274
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001305020.1NP_001291949.1  KRAB domain-containing protein ZNF747 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate segment in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. These differences result in a frameshift compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA316824, AB209546, BC001361, BE327668, BM461939, BP359683, CA429734
    Consensus CDS
    CCDS76855.1
    UniProtKB/Swiss-Prot
    Q9BV97
    Related
    ENSP00000378528.3, ENST00000395094.3
    Conserved Domains (2) summary
    smart00349
    Location:3777
    KRAB; krueppel associated box
    pfam01352
    Location:3776
    KRAB; KRAB box
  4. NM_023931.3NP_076420.1  KRAB domain-containing protein ZNF747 isoform 3

    See identical proteins and their annotated locations for NP_076420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate segment in the 5' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA316824, BC001361, BE327668, BM461939, BP359683, CA429734
    Consensus CDS
    CCDS10682.1
    UniProtKB/Swiss-Prot
    Q9BV97
    UniProtKB/TrEMBL
    A0A024QZG5
    Related
    ENSP00000252799.3, ENST00000252799.3
    Conserved Domains (1) summary
    pfam01352
    Location:3777
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30530367..30534970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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