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CAPRIN2 caprin family member 2 [ Homo sapiens (human) ]

Gene ID: 65981, updated on 5-Nov-2017
Official Symbol
CAPRIN2provided by HGNC
Official Full Name
caprin family member 2provided by HGNC
Primary source
HGNC:HGNC:21259
See related
Ensembl:ENSG00000110888 MIM:610375; Vega:OTTHUMG00000169185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EEG1; EEG-1; C1QDC1; RNG140
Summary
The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in testis (RPKM 12.6), brain (RPKM 7.2) and 25 other tissues See more
Orthologs
Location:
12p11.21
Exon count:
20
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (30709552..30754994, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (30862486..30907448, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369720 Neighboring gene importin 8 Neighboring gene uncharacterized LOC645485 Neighboring gene long intergenic non-protein coding RNA 941

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11391, FLJ22569, KIAA1873, MGC102894, MGC134847, MGC134848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
caprin-2
Names
C1q domain-containing protein 1
RNA granule protein 140
cytoplasmic activation/proliferation-associated protein 2
gastric cancer multidrug resistance-associated protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029557.2 RefSeqGene

    Range
    5001..49963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002259.2NP_001002259.1  caprin-2 isoform 1

    See identical proteins and their annotated locations for NP_001002259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). This variant is supported by BK001102.1, which is a third party annotation described in PMID:14764709.
    Source sequence(s)
    AK021453, AL834212, AY074490, AY074491, BC025420, BQ010043, KF455635
    UniProtKB/Swiss-Prot
    Q6IMN6
    Conserved Domains (3) summary
    pfam05483
    Location:88540
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9991124
    C1q; C1q domain
    pfam12287
    Location:628929
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  2. NM_001206856.2NP_001193785.1  caprin-2 isoform 4

    See identical proteins and their annotated locations for NP_001193785.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, and uses an alternate splice site in the 3' coding region that causes a frameshift, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC010198, BC007520, BC117673, BR000870, KF455635
    Consensus CDS
    CCDS55816.1
    UniProtKB/Swiss-Prot
    Q6IMN6
    Related
    ENSP00000379150.2, OTTHUMP00000240691, ENST00000395805.6, OTTHUMT00000403322
    Conserved Domains (2) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam12287
    Location:628873
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  3. NM_001319842.1NP_001306771.1  caprin-2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 5' region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (5) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC010198, AY074491, BC007520, KF455635
    UniProtKB/Swiss-Prot
    Q6IMN6
    Conserved Domains (2) summary
    pfam00386
    Location:665790
    C1q; C1q domain
    pfam12287
    Location:295595
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  4. NM_001319843.1NP_001306772.1  caprin-2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (6) is shorter than isoform 1. This variant is supported by BK001102.1, which is a third party annotation described in PMID:14764709.
    Source sequence(s)
    BK001103, BR000870
    UniProtKB/Swiss-Prot
    Q6IMN6
    Conserved Domains (3) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9981123
    C1q; C1q domain
    pfam12287
    Location:628928
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  5. NM_001319844.1NP_001306773.1  caprin-2 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (7) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC010198
    Conserved Domains (3) summary
    pfam05483
    Location:7429
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:8831008
    C1q; C1q domain
    pfam12287
    Location:547813
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  6. NM_001319845.1NP_001306774.1  caprin-2 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (8) has a shorter N-terminus than isoform 1. Variants 8 and 9 encode the same isoform (8).
    Source sequence(s)
    AC010198
    Conserved Domains (3) summary
    pfam05483
    Location:7429
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9181043
    C1q; C1q domain
    pfam12287
    Location:547848
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  7. NM_001319846.1NP_001306775.1  caprin-2 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (8) has a shorter N-terminus than isoform 1. Variants 8 and 9 encode the same isoform (8).
    Source sequence(s)
    AC010198
    Conserved Domains (3) summary
    pfam05483
    Location:7429
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9181043
    C1q; C1q domain
    pfam12287
    Location:547848
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  8. NM_023925.4NP_076414.2  caprin-2 isoform 2

    See identical proteins and their annotated locations for NP_076414.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as EEGL) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK021453, AL834212, AY074490, AY074491, BC025420, BQ010043, KF455635
    Consensus CDS
    CCDS8720.1
    UniProtKB/Swiss-Prot
    Q6IMN6
    Related
    ENSP00000298892.5, OTTHUMP00000240356, ENST00000298892.9, OTTHUMT00000402778
    Conserved Domains (3) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9491074
    C1q; C1q domain
    pfam12287
    Location:628879
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  9. NM_032156.4NP_115532.3  caprin-2 isoform 3

    See identical proteins and their annotated locations for NP_115532.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and an alternate splice site in the 3' coding region that causes a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC007520, BC117672, BR000870, KF455635
    Consensus CDS
    CCDS41766.2
    UniProtKB/Swiss-Prot
    Q6IMN6
    Related
    ENSP00000391479.1, OTTHUMP00000240692, ENST00000417045.5, OTTHUMT00000403323
    Conserved Domains (2) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam12287
    Location:628928
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

    Range
    30709552..30754994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019871.1XP_016875360.1  caprin-2 isoform X24

    Related
    ENSP00000438010.1, OTTHUMP00000240693, ENST00000537108.5, OTTHUMT00000403324
  2. XM_017019853.1XP_016875342.1  caprin-2 isoform X6

  3. XM_017019875.1XP_016875364.1  caprin-2 isoform X28

  4. XM_017019861.1XP_016875350.1  caprin-2 isoform X15

  5. XM_017019873.1XP_016875362.1  caprin-2 isoform X26

  6. XM_017019872.1XP_016875361.1  caprin-2 isoform X25

  7. XM_017019858.1XP_016875347.1  caprin-2 isoform X11

  8. XM_017019856.1XP_016875345.1  caprin-2 isoform X10

    Conserved Domains (3) summary
    pfam05483
    Location:7429
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:8831008
    C1q; C1q domain
    pfam12287
    Location:547813
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  9. XM_017019855.1XP_016875344.1  caprin-2 isoform X9

  10. XM_017019869.1XP_016875358.1  caprin-2 isoform X23

  11. XM_017019867.1XP_016875356.1  caprin-2 isoform X22

  12. XM_017019879.1XP_016875368.1  caprin-2 isoform X32

  13. XM_017019882.1XP_016875371.1  caprin-2 isoform X35

  14. XM_017019874.1XP_016875363.1  caprin-2 isoform X27

    Conserved Domains (2) summary
    pfam00386
    Location:665790
    C1q; C1q domain
    pfam12287
    Location:295595
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  15. XM_017019881.1XP_016875370.1  caprin-2 isoform X34

    Related
    ENSP00000415407.2, OTTHUMP00000240689, ENST00000433722.6, OTTHUMT00000403320
  16. XM_017019859.1XP_016875348.1  caprin-2 isoform X12

  17. XM_017019857.1XP_016875346.1  caprin-2 isoform X11

  18. XM_017019870.1XP_016875359.1  caprin-2 isoform X24

  19. XM_017019852.1XP_016875341.1  caprin-2 isoform X6

  20. XM_017019868.1XP_016875357.1  caprin-2 isoform X23

  21. XM_017019866.1XP_016875355.1  caprin-2 isoform X22

  22. XM_017019854.1XP_016875343.1  caprin-2 isoform X8

  23. XM_006719144.3XP_006719207.1  caprin-2 isoform X7

    Conserved Domains (3) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9151040
    C1q; C1q domain
    pfam12287
    Location:628845
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  24. XM_017019851.1XP_016875340.1  caprin-2 isoform X4

  25. XM_006719140.3XP_006719203.1  caprin-2 isoform X3

    Conserved Domains (3) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9631088
    C1q; C1q domain
    pfam12287
    Location:628893
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  26. XM_006719139.3XP_006719202.1  caprin-2 isoform X2

    Conserved Domains (3) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9641089
    C1q; C1q domain
    pfam12287
    Location:628894
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  27. XM_017019865.1XP_016875354.1  caprin-2 isoform X21

  28. XM_006719142.3XP_006719205.1  caprin-2 isoform X5

    Conserved Domains (3) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9291054
    C1q; C1q domain
    pfam12287
    Location:628859
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  29. XM_006719138.3XP_006719201.1  caprin-2 isoform X1

    Conserved Domains (3) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam00386
    Location:9781103
    C1q; C1q domain
    pfam12287
    Location:628908
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  30. XM_006719147.3XP_006719210.1  caprin-2 isoform X20

    UniProtKB/Swiss-Prot
    Q6IMN6
    Conserved Domains (2) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam12287
    Location:628908
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  31. XM_006719145.3XP_006719208.1  caprin-2 isoform X13

    Conserved Domains (2) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam12287
    Location:628929
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  32. XM_017019880.1XP_016875369.1  caprin-2 isoform X33

  33. XM_017019878.1XP_016875367.1  caprin-2 isoform X31

  34. XM_017019877.1XP_016875366.1  caprin-2 isoform X30

  35. XM_017019883.1XP_016875372.1  caprin-2 isoform X36

  36. XM_017019876.1XP_016875365.1  caprin-2 isoform X29

  37. XM_017019862.1XP_016875351.1  caprin-2 isoform X16

  38. XM_017019860.1XP_016875349.1  caprin-2 isoform X14

  39. XM_006719146.3XP_006719209.1  caprin-2 isoform X19

    Conserved Domains (2) summary
    pfam05483
    Location:88510
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam12287
    Location:628929
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  40. XM_017019863.1XP_016875352.1  caprin-2 isoform X17

  41. XM_017019864.1XP_016875353.1  caprin-2 isoform X18

RNA

  1. XR_931325.2 RNA Sequence

    Related
    ENST00000454014.6, OTTHUMT00000403321

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    30827509..30872908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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