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STK33 serine/threonine kinase 33 [ Homo sapiens (human) ]

Gene ID: 65975, updated on 4-Dec-2022

Summary

Official Symbol
STK33provided by HGNC
Official Full Name
serine/threonine kinase 33provided by HGNC
Primary source
HGNC:HGNC:14568
See related
Ensembl:ENSG00000130413 MIM:607670; AllianceGenome:HGNC:14568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling and protein autophosphorylation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 7.0), thyroid (RPKM 2.1) and 11 other tissues See more
Orthologs
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Genomic context

See STK33 in Genome Data Viewer
Location:
11p15.4
Exon count:
24
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (8334824..8594228, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8473059..8675974, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8413417..8615775, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376536 Neighboring gene LIM domain only 1 Neighboring gene Sharpr-MPRA regulatory region 11418 Neighboring gene small Cajal body-specific RNA 20 Neighboring gene tripartite motif containing 66 Neighboring gene small nucleolar RNA, H/ACA box 3A Neighboring gene ribosomal protein L27a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
EBI GWAS Catalog
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in mitotic DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 33
NP_001275987.1
NP_001275988.1
NP_001275990.1
NP_001339316.1
NP_001339317.1
NP_001339318.1
NP_001339319.1
NP_001339320.1
NP_001339321.1
NP_001339322.1
NP_001339323.1
NP_001339324.1
NP_001339325.1
NP_001339326.1
NP_001339327.1
NP_001339328.1
NP_112168.1
XP_011518592.1
XP_011518599.1
XP_016873633.1
XP_016873634.1
XP_016873635.1
XP_016873643.1
XP_016873644.1
XP_016873646.1
XP_047283403.1
XP_047283404.1
XP_047283405.1
XP_047283406.1
XP_047283407.1
XP_047283408.1
XP_047283409.1
XP_047283410.1
XP_047283411.1
XP_047283412.1
XP_047283413.1
XP_047283414.1
XP_047283415.1
XP_047283416.1
XP_047283417.1
XP_047283418.1
XP_047283419.1
XP_047283420.1
XP_047283421.1
XP_047283422.1
XP_047283423.1
XP_047283424.1
XP_047283425.1
XP_047283426.1
XP_047283427.1
XP_047283428.1
XP_047283429.1
XP_047283430.1
XP_047283431.1
XP_047283432.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289058.2NP_001275987.1  serine/threonine-protein kinase 33 isoform b

    See identical proteins and their annotated locations for NP_001275987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region, and uses a downstream translation initiation codon, compared to variant 1. This results in a protein (isoform b) with a shorter C-terminus, compared to isoform a. Variants 2, 12, and 13 all encode the same isoform (b).
    Source sequence(s)
    AJ303380, AK293193, BU580591, DA348768
    Consensus CDS
    CCDS73254.1
    UniProtKB/Swiss-Prot
    Q9BYT3
    UniProtKB/TrEMBL
    B4DDH2
    Related
    ENSP00000436418.1, ENST00000534493.5
    Conserved Domains (1) summary
    cd14097
    Location:73340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  2. NM_001289059.2NP_001275988.1  serine/threonine-protein kinase 33 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the coding region, and uses a downstream translation initiation codon, compared to variant 1. This results in a protein (isoform c) with a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC105357, AJ303380, AK092720, BU580591, DA348768
    Consensus CDS
    CCDS73253.1
    UniProtKB/Swiss-Prot
    Q9BYT3
    UniProtKB/TrEMBL
    B3KS39, F8WAK5
    Related
    ENSP00000351743.3, ENST00000358872.7
    Conserved Domains (2) summary
    smart00220
    Location:1194
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1194
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001289061.2NP_001275990.1  serine/threonine-protein kinase 33 isoform a

    See identical proteins and their annotated locations for NP_001275990.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4-11 all encode the same isoform (a).
    Source sequence(s)
    AJ303380, AK093251, BC031231, BU580591, DB049619
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5, Q9BYT3
    Related
    ENSP00000379905.1, ENST00000396672.5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  4. NM_001352387.2NP_001339316.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 4, and 6-11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  5. NM_001352388.2NP_001339317.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7-11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  6. NM_001352389.2NP_001339318.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 4-6, and 8-11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5
    Related
    ENSP00000509322.1, ENST00000687296.1
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  7. NM_001352390.2NP_001339319.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 4-7, and 9-11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  8. NM_001352391.2NP_001339320.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 4-8, 10, and 11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  9. NM_001352392.2NP_001339321.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 4-9, and 11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  10. NM_001352393.2NP_001339322.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 1 and 4-10, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  11. NM_001352394.2NP_001339323.1  serine/threonine-protein kinase 33 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 2 and 13, encodes isoform b.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS73254.1
    UniProtKB/TrEMBL
    B4DDH2
    Conserved Domains (1) summary
    cd14097
    Location:73340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  12. NM_001352395.2NP_001339324.1  serine/threonine-protein kinase 33 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 2 and 12, encodes isoform b.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS73254.1
    UniProtKB/TrEMBL
    B4DDH2
    Conserved Domains (1) summary
    cd14097
    Location:73340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  13. NM_001352396.2NP_001339325.1  serine/threonine-protein kinase 33 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 15 and 16, encodes isoform d.
    Source sequence(s)
    AC104360, AC105357
    Conserved Domains (1) summary
    cd14097
    Location:73340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  14. NM_001352397.2NP_001339326.1  serine/threonine-protein kinase 33 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform d.
    Source sequence(s)
    AC104360, AC105357
    Conserved Domains (1) summary
    cd14097
    Location:73340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  15. NM_001352398.2NP_001339327.1  serine/threonine-protein kinase 33 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 14 and 15, encodes isoform d.
    Source sequence(s)
    AC104360, AC105357
    Conserved Domains (1) summary
    cd14097
    Location:73340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  16. NM_001352399.2NP_001339328.1  serine/threonine-protein kinase 33 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC104360, AC105357
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  17. NM_030906.4NP_112168.1  serine/threonine-protein kinase 33 isoform a

    See identical proteins and their annotated locations for NP_112168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 4-11 all encode the same isoform (a).
    Source sequence(s)
    AJ303380, AK093251, BC031231, BU580591, DB049619
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q8NEF5, Q9BYT3
    Related
    ENSP00000320754.1, ENST00000315204.5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    8334824..8594228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427469.1XP_047283425.1  serine/threonine-protein kinase 33 isoform X3

  2. XM_047427463.1XP_047283419.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    B4DDH2
  3. XM_017018157.2XP_016873646.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    B4DDH2
    Conserved Domains (1) summary
    cd14097
    Location:73340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  4. XM_047427473.1XP_047283429.1  serine/threonine-protein kinase 33 isoform X4

  5. XM_047427474.1XP_047283430.1  serine/threonine-protein kinase 33 isoform X4

  6. XM_047427459.1XP_047283415.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  7. XM_047427458.1XP_047283414.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  8. XM_047427476.1XP_047283432.1  serine/threonine-protein kinase 33 isoform X5

  9. XM_047427465.1XP_047283421.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    B4DDH2
  10. XM_047427472.1XP_047283428.1  serine/threonine-protein kinase 33 isoform X4

  11. XM_047427448.1XP_047283404.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  12. XM_047427451.1XP_047283407.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  13. XM_047427468.1XP_047283424.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    B4DDH2
  14. XM_047427467.1XP_047283423.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    B4DDH2
  15. XM_047427449.1XP_047283405.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  16. XM_047427475.1XP_047283431.1  serine/threonine-protein kinase 33 isoform X4

  17. XM_017018144.3XP_016873633.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5, Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  18. XM_047427460.1XP_047283416.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  19. XM_047427452.1XP_047283408.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  20. XM_047427464.1XP_047283420.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    B4DDH2
  21. XM_047427470.1XP_047283426.1  serine/threonine-protein kinase 33 isoform X4

  22. XM_047427450.1XP_047283406.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  23. XM_011520297.3XP_011518599.1  serine/threonine-protein kinase 33 isoform X2

    See identical proteins and their annotated locations for XP_011518599.1

    UniProtKB/TrEMBL
    B4DDH2
    Conserved Domains (1) summary
    cd14097
    Location:73340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  24. XM_047427466.1XP_047283422.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    B4DDH2
  25. XM_047427462.1XP_047283418.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  26. XM_047427454.1XP_047283410.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  27. XM_047427456.1XP_047283412.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  28. XM_047427457.1XP_047283413.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  29. XM_011520290.3XP_011518592.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011518592.1

    UniProtKB/Swiss-Prot
    Q8NEF5, Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  30. XM_047427455.1XP_047283411.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  31. XM_047427447.1XP_047283403.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  32. XM_047427453.1XP_047283409.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  33. XM_017018146.2XP_016873635.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5, Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  34. XM_017018145.2XP_016873634.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5, Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  35. XM_017018154.2XP_016873643.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5, Q9BYT3
    Related
    ENSP00000416750.1, ENST00000447869.5
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33
  36. XM_047427461.1XP_047283417.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5
  37. XM_047427471.1XP_047283427.1  serine/threonine-protein kinase 33 isoform X4

  38. XM_017018155.3XP_016873644.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEF5, Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

RNA

  1. XR_007062494.1 RNA Sequence

  2. XR_001747939.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    8473059..8675974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)