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STK33 serine/threonine kinase 33 [ Homo sapiens (human) ]

Gene ID: 65975, updated on 24-Nov-2020

Summary

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Official Symbol
STK33provided by HGNC
Official Full Name
serine/threonine kinase 33provided by HGNC
Primary source
HGNC:HGNC:14568
See related
Ensembl:ENSG00000130413 MIM:607670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 7.0), thyroid (RPKM 2.1) and 11 other tissues See more
Orthologs
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Genomic context

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See STK33 in Genome Data Viewer
Location:
11p15.4
Exon count:
25
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (8335029..8594228, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8413417..8615836, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1859 Neighboring gene uncharacterized LOC105376536 Neighboring gene LIM domain only 1 Neighboring gene tripartite motif containing 66 Neighboring gene small nucleolar RNA, H/ACA box 3A Neighboring gene ribosomal protein L27a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α. Kong F, et al. Cancer Res, 2017 Dec 15. PMID 29038348
  2. Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction. Sun EL, et al. Neoplasma, 2017. PMID 28895411
  3. STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium. Chen C, et al. Cancer Biol Ther, 2016 Sep. PMID 27414193, Free PMC Article
  4. STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential. Wang P, et al. Acta Biochim Biophys Sin (Shanghai), 2015 Mar. PMID 25662617
  5. STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis. Huang L, et al. BMC Cancer, 2015 Jan 21. PMID 25603720, Free PMC Article

See all (30) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that serine/threonine kinase 33 (STK33) can bind with extracellular signal-regulated kinase 2 (ERK2) and take part in the regulation of ERKs signaling pathway.
    Title: STK33/ERK2 signal pathway contribute the tumorigenesis of colorectal cancer HCT15 cells.
  2. STK33 has pro-tumor function and is a critical downstream mediator of KLF4 in gastric cancer. STK33 may serve as a potential prognostic marker and therapeutic target for gastric cancer.
    Title: Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.
  3. inhibition of STK33 in small cell lung carcinoma cells suppressed the cell proliferation and invasion while induced cell apoptosis
    Title: Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
  4. Dysregulated HIF1alpha/STK33 signaling promotes pancreatic ductal adenocarcinoma (PDAC) growth and progression, this suggests that STK33 is a candidate therapeutic target to improve PDAC treatment.
    Title: STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α.
  5. STK33 is a potential oncogene and plays an important role in tumorigenesis of HSCC via regulation of numerous genes.
    Title: STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
  6. STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity.
    Title: STK33 promotes hepatocellular carcinoma through binding to c-Myc.
  7. Results show that STK33 is a potential oncogene and a promising diagnostic marker for hypopharyngeal squamous cell carcinoma (HSCC). STK33 may promote tumorigenesis and progression of HSCC, and serve as a valuable molecular target for treatment of HSCC.
    Title: STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
  8. STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 large cell lung cancer cell lines. In addition, this protein also promotes epithelial-mesenchymal transition.
    Title: STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential.
  9. The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.
    Title: The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.
  10. STK33 downregulation or dominant mutant overexpression had no effect on KRAS signaling or survival of cancer cells.
    Title: STK33 kinase activity is nonessential in KRAS-dependent cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
GeneReviews: Not available
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
  
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
mitotic DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
signal transduction in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 33
NP_001275987.1
NP_001275988.1
NP_001275990.1
NP_001339316.1
NP_001339317.1
NP_001339318.1
NP_001339319.1
NP_001339320.1
NP_001339321.1
NP_001339322.1
NP_001339323.1
NP_001339324.1
NP_001339325.1
NP_001339326.1
NP_001339327.1
NP_001339328.1
NP_112168.1
XP_011518592.1
XP_011518597.1
XP_011518599.1
XP_016873633.1
XP_016873634.1
XP_016873635.1
XP_016873636.1
XP_016873637.1
XP_016873641.1
XP_016873642.1
XP_016873643.1
XP_016873644.1
XP_016873645.1
XP_016873646.1
XP_016873648.1
XP_016873650.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289058.2 → NP_001275987.1  serine/threonine-protein kinase 33 isoform b

    See identical proteins and their annotated locations for NP_001275987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region, and uses a downstream translation initiation codon, compared to variant 1. This results in a protein (isoform b) with a shorter C-terminus, compared to isoform a. Variants 2, 12, and 13 all encode the same isoform (b).
    Source sequence(s)
    AJ303380, AK293193, BU580591, DA348768
    Consensus CDS
    CCDS73254.1
    UniProtKB/Swiss-Prot
    Q9BYT3
    UniProtKB/TrEMBL
    B4DDH2
    Related
    ENSP00000436418.1, ENST00000534493.5
    Conserved Domains (1) summary
    cd14097
    Location:73 → 340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  2. NM_001289059.2 → NP_001275988.1  serine/threonine-protein kinase 33 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the coding region, and uses a downstream translation initiation codon, compared to variant 1. This results in a protein (isoform c) with a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC105357, AJ303380, AK092720, BU580591, DA348768
    Consensus CDS
    CCDS73253.1
    UniProtKB/Swiss-Prot
    Q9BYT3
    UniProtKB/TrEMBL
    B3KS39, F8WAK5
    Related
    ENSP00000351743.3, ENST00000358872.7
    Conserved Domains (2) summary
    smart00220
    Location:1 → 194
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 194
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001289061.2 → NP_001275990.1  serine/threonine-protein kinase 33 isoform a

    See identical proteins and their annotated locations for NP_001275990.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4-11 all encode the same isoform (a).
    Source sequence(s)
    AJ303380, AK093251, BC031231, BU580591, DB049619
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q9BYT3
    Related
    ENSP00000379905.1, ENST00000396672.5
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  4. NM_001352387.2 → NP_001339316.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 4, and 6-11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  5. NM_001352388.2 → NP_001339317.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7-11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  6. NM_001352389.2 → NP_001339318.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 4-6, and 8-11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  7. NM_001352390.2 → NP_001339319.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 4-7, and 9-11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  8. NM_001352391.2 → NP_001339320.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 4-8, 10, and 11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  9. NM_001352392.2 → NP_001339321.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 4-9, and 11, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  10. NM_001352393.2 → NP_001339322.1  serine/threonine-protein kinase 33 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 1 and 4-10, encodes isoform a.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS7789.1
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  11. NM_001352394.2 → NP_001339323.1  serine/threonine-protein kinase 33 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 2 and 13, encodes isoform b.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS73254.1
    Conserved Domains (1) summary
    cd14097
    Location:73 → 340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  12. NM_001352395.2 → NP_001339324.1  serine/threonine-protein kinase 33 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 2 and 12, encodes isoform b.
    Source sequence(s)
    AC104360, AC105357
    Consensus CDS
    CCDS73254.1
    Conserved Domains (1) summary
    cd14097
    Location:73 → 340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  13. NM_001352396.2 → NP_001339325.1  serine/threonine-protein kinase 33 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 15 and 16, encodes isoform d.
    Source sequence(s)
    AC104360, AC105357
    Conserved Domains (1) summary
    cd14097
    Location:73 → 340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  14. NM_001352397.2 → NP_001339326.1  serine/threonine-protein kinase 33 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform d.
    Source sequence(s)
    AC104360, AC105357
    Conserved Domains (1) summary
    cd14097
    Location:73 → 340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  15. NM_001352398.2 → NP_001339327.1  serine/threonine-protein kinase 33 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 14 and 15, encodes isoform d.
    Source sequence(s)
    AC104360, AC105357
    Conserved Domains (1) summary
    cd14097
    Location:73 → 340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  16. NM_001352399.2 → NP_001339328.1  serine/threonine-protein kinase 33 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC104360, AC105357
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  17. NM_030906.4 → NP_112168.1  serine/threonine-protein kinase 33 isoform a

    See identical proteins and their annotated locations for NP_112168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 4-11 all encode the same isoform (a).
    Source sequence(s)
    AJ303380, AK093251, BC031231, BU580591, DB049619
    Consensus CDS
    CCDS7789.1
    UniProtKB/Swiss-Prot
    Q9BYT3
    Related
    ENSP00000320754.1, ENST00000315204.5
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    8335029..8594228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018144.2 → XP_016873633.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  2. XM_011520290.2 → XP_011518592.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011518592.1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  3. XM_017018146.1 → XP_016873635.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  4. XM_011520297.2 → XP_011518599.1  serine/threonine-protein kinase 33 isoform X2

    See identical proteins and their annotated locations for XP_011518599.1

    UniProtKB/TrEMBL
    B4DDH2
    Conserved Domains (1) summary
    cd14097
    Location:73 → 340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  5. XM_017018153.2 → XP_016873642.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  6. XM_017018156.1 → XP_016873645.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  7. XM_017018152.1 → XP_016873641.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  8. XM_017018154.1 → XP_016873643.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Related
    ENSP00000416750.1, ENST00000447869.5
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  9. XM_017018159.1 → XP_016873648.1  serine/threonine-protein kinase 33 isoform X3

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  10. XM_017018148.1 → XP_016873637.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  11. XM_017018147.1 → XP_016873636.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  12. XM_011520295.2 → XP_011518597.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011518597.1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  13. XM_017018145.1 → XP_016873634.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  14. XM_017018157.1 → XP_016873646.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    B4DDH2
    Conserved Domains (1) summary
    cd14097
    Location:73 → 340
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  15. XM_017018155.2 → XP_016873644.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYT3
    Conserved Domains (1) summary
    cd14097
    Location:114 → 381
    STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

  16. XM_017018161.1 → XP_016873650.1  serine/threonine-protein kinase 33 isoform X4

RNA

  1. XR_001747938.1 RNA Sequence

  2. XR_001747939.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYT3.1 GenPept UniProtKB/Swiss-Prot:Q9BYT3

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