U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ifi30 interferon gamma inducible protein 30 [ Mus musculus (house mouse) ]

Gene ID: 65972, updated on 12-May-2024

Summary

Official Symbol
Ifi30provided by MGI
Official Full Name
interferon gamma inducible protein 30provided by MGI
Primary source
MGI:MGI:2137648
See related
Ensembl:ENSMUSG00000031838 AllianceGenome:MGI:2137648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GILT; IP30
Summary
Predicted to enable oxidoreductase activity, acting on a sulfur group of donors. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of fibroblast proliferation; and protein stabilization. Located in lysosome. Is expressed in alimentary system; liver; and orbito-sphenoid. Orthologous to human IFI30 (IFI30 lysosomal thiol reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 275.5), duodenum adult (RPKM 244.1) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ifi30 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71215418..71219307, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70762773..70766663, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1370 Neighboring gene RAB3A, member RAS oncogene family Neighboring gene MPV17 mitochondrial membrane protein-like 2 Neighboring gene RIKEN cDNA 6330537M06 gene Neighboring gene STARR-positive B cell enhancer ABC_E190 Neighboring gene STARR-positive B cell enhancer ABC_E10506 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene RIKEN cDNA 2010320M18 gene Neighboring gene STARR-positive B cell enhancer ABC_E8241 Neighboring gene STARR-positive B cell enhancer ABC_E6649

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-interferon-inducible lysosomal thiol reductase
Names
gamma-interferon-inducible protein IP-30
lysosomal thio reductase IP30
lysosomal thiol reductase IP30

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023065.3NP_075552.2  gamma-interferon-inducible lysosomal thiol reductase precursor

    See identical proteins and their annotated locations for NP_075552.2

    Status: VALIDATED

    Source sequence(s)
    AF309649, BE951500, BQ746455, BY774497
    UniProtKB/Swiss-Prot
    G3X911, Q3U0F9, Q9EP56, Q9ESY9
    Related
    ENSMUSP00000159394.2, ENSMUST00000222087.4
    Conserved Domains (1) summary
    pfam03227
    Location:61163
    GILT; Gamma interferon inducible lysosomal thiol reductase (GILT)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71215418..71219307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)