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Tmem176b transmembrane protein 176B [ Mus musculus (house mouse) ]

Gene ID: 65963, updated on 26-Sep-2022

Summary

Official Symbol
Tmem176bprovided by MGI
Official Full Name
transmembrane protein 176Bprovided by MGI
Primary source
MGI:MGI:1916348
See related
Ensembl:ENSMUSG00000029810 AllianceGenome:MGI:1916348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lr8; Clast1; 1810009M01Rik
Summary
Acts upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane and nucleus. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human TMEM176B (transmembrane protein 176B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 289.3), adrenal adult (RPKM 166.2) and 22 other tissues See more
Orthologs
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Genomic context

See Tmem176b in Genome Data Viewer
Location:
6 B2.3; 6 23.75 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48810745..48818363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48833811..48845948, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30781 Neighboring gene septin 7 pseudogene Neighboring gene transmembrane protein 176A Neighboring gene predicted gene 44764 Neighboring gene predicted gene 7932

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164207.1NP_001157679.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001157679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC115045, AK007408, BE457679, DV047496
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000131064.2, ENSMUST00000166247.8
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  2. NM_001164208.1NP_001157680.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001157680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC115045, AK007408, BE457679, BQ571258, DV047496
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  3. NM_001164209.2NP_001157681.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001157681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AK007408, BE457679, CX213755, CX223561, DV047496
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000098972.5, ENSMUST00000101429.11
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  4. NM_001286651.1NP_001273580.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001273580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AK007408, BE457679, CX213755, CX223561, DV047496
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  5. NM_001286652.1NP_001273581.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001273581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AK007408, BE457679, CX213755, CX223561, DV059241
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000144864.2, ENSMUST00000204073.3
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  6. NM_023056.4NP_075543.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_075543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AB031386, AC115045, BE457679
    Consensus CDS
    CCDS20116.1
    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Related
    ENSMUSP00000128705.2, ENSMUST00000164733.4
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family

RNA

  1. NR_104575.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' terminal exon and lacks an exon in the 5' region, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK007408, BE457679, CX213755, CX223561, DV047496

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48810745..48818363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152260.1XP_036008153.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  2. XM_006506459.5XP_006506522.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506522.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  3. XM_030255531.2XP_030111391.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  4. XM_006506458.4XP_006506521.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506521.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  5. XM_006506457.5XP_006506520.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506520.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  6. XM_030255532.2XP_030111392.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9WU52
    Related
    ENSMUSP00000145395.2, ENSMUST00000203355.3
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  7. XM_030255534.2XP_030111394.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  8. XM_006506456.5XP_006506519.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506519.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  9. XM_017321710.3XP_017177199.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  10. XM_006506460.5XP_006506523.1  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006506523.1

    UniProtKB/Swiss-Prot
    Q9R1Q6, Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  11. XM_030255533.2XP_030111393.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family
  12. XM_030255535.2XP_030111395.1  transmembrane protein 176B isoform X1

    UniProtKB/Swiss-Prot
    Q9WU52
    Conserved Domains (1) summary
    pfam04103
    Location:60224
    CD20; CD20-like family