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Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 65962, updated on 5-Jan-2022

Summary

Official Symbol
Slc9a3r2provided by MGI
Official Full Name
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2provided by MGI
Primary source
MGI:MGI:1890662
See related
Ensembl:ENSMUSG00000002504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sip1; Octs2; Sip-1; Tka-1; E3karp; Nherf2; Sryip1; NHERF-2; 0610011L07Rik; 1200011K07Rik; 2010007A20Rik
Summary
Enables phosphatase binding activity. Acts upstream of or within negative regulation of phosphatidylinositol 3-kinase signaling and sensory perception of sound. Located in several cellular components, including apical plasma membrane; nucleus; and stereocilium. Is expressed in cochlea epithelium and organ of Corti. Orthologous to human SLC9A3R2 (SLC9A3 regulator 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in lung adult (RPKM 219.2), ovary adult (RPKM 58.5) and 18 other tissues See more
Orthologs
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Genomic context

See Slc9a3r2 in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24858255..24869279, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24639281..24650305, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24776227..24787250, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene TSC complex subunit 2 Neighboring gene nth (endonuclease III)-like 1 (E.coli) Neighboring gene neuropeptide W Neighboring gene zinc finger protein 598

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in stereocilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium bundle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Names
NHE3 kinase A regulatory protein E3KARP
SRY-interacting protein 1
sodium-hydrogen exchanger regulatory factor 2
tyrosine kinase activator protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357796.1NP_001344725.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform C

    Status: VALIDATED

    Source sequence(s)
    AK075813, BC070458
    Consensus CDS
    CCDS89012.1
    Related
    ENSMUSP00000157103.2, ENSMUST00000234557.2
    Conserved Domains (3) summary
    smart00228
    Location:148230
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:988
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09007
    Location:232316
    EBP50_C; EBP50, C-terminal
  2. NM_023055.2NP_075542.2  Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform A

    See identical proteins and their annotated locations for NP_075542.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longer isoform (A).
    Source sequence(s)
    AK084801, CJ194744
    Consensus CDS
    CCDS28488.1
    UniProtKB/Swiss-Prot
    Q9JHL1
    UniProtKB/TrEMBL
    A0A0R4IZX2
    Related
    ENSMUSP00000002572.5, ENSMUST00000002572.6
    Conserved Domains (3) summary
    smart00228
    Location:148230
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:988
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09007
    Location:232337
    EBP50_C; EBP50, C-terminal
  3. NM_023449.3NP_075938.2  Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform B

    See identical proteins and their annotated locations for NP_075938.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR and 5' coding region, compared to variant A. The resulting isoform (B) has a shorter and distinct N-terminus, compared to isoform A.
    Source sequence(s)
    AK002557, AK039491, CJ194744
    Consensus CDS
    CCDS28489.1
    UniProtKB/Swiss-Prot
    Q9JHL1
    UniProtKB/TrEMBL
    A0A0R4J006
    Related
    ENSMUSP00000019684.6, ENSMUST00000019684.13
    Conserved Domains (2) summary
    cd00992
    Location:38117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09007
    Location:121226
    EBP50_C; EBP50, C-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24858255..24869279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249980.2XP_030105840.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform X1

    Related
    ENSMUSP00000157065.2, ENSMUST00000234505.2
    Conserved Domains (2) summary
    cd00992
    Location:38117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09007
    Location:121205
    EBP50_C; EBP50, C-terminal
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