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SLPI secretory leukocyte peptidase inhibitor [ Homo sapiens (human) ]

Gene ID: 6590, updated on 24-Nov-2020

Summary

Official Symbol
SLPIprovided by HGNC
Official Full Name
secretory leukocyte peptidase inhibitorprovided by HGNC
Primary source
HGNC:HGNC:11092
See related
Ensembl:ENSG00000124107 MIM:107285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I
Summary
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
Expression
Biased expression in salivary gland (RPKM 1077.5), lung (RPKM 390.4) and 4 other tissues See more
Orthologs

Genomic context

See SLPI in Genome Data Viewer
Location:
20q13.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (45252239..45254564, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43880880..43883205, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene semenogelin 1 Neighboring gene uncharacterized LOC105372630 Neighboring gene semenogelin 2 Neighboring gene matrilin 4 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region like Neighboring gene tRNA-Val (anticodon CAC) 14-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The expression and production of secretory leukocyte protease inhibitor (SLPI), a 12-kDa mucosal antiviral protein, can be stimulated in oral epithelial cells through interactions with HIV-1 gp120 PubMed
retropepsin gag-pol Secretory levels of secretory leukocyte peptidase inhibitor (SLPI) from HIV-1 infected patients is enhanced in saliva PubMed
gag-pol Human secretory leukocyte protease inhibitor (hSLPI) inhibits HIV-1 infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
antibacterial humoral response ISS
Inferred from Sequence or Structural Similarity
more info
 
immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
modulation of process of other organism IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
antileukoproteinase
Names
HUSI-1
WAP four-disulfide core domain protein 4
mucus proteinase inhibitor
protease inhibitor WAP4
secretory leukocyte protease inhibitor (antileukoproteinase)
seminal proteinase inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028137.1 RefSeqGene

    Range
    5002..7327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003064.4NP_003055.1  antileukoproteinase precursor

    See identical proteins and their annotated locations for NP_003055.1

    Status: REVIEWED

    Source sequence(s)
    BC020708
    Consensus CDS
    CCDS13347.1
    UniProtKB/Swiss-Prot
    P03973
    Related
    ENSP00000342082.2, ENST00000338380.2
    Conserved Domains (2) summary
    smart00217
    Location:85130
    WAP; Four-disulfide core domains
    pfam00095
    Location:3173
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    45252239..45254564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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