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SLN sarcolipin [ Homo sapiens (human) ]

Gene ID: 6588, updated on 15-Mar-2020

Summary

Official Symbol
SLNprovided by HGNC
Official Full Name
sarcolipinprovided by HGNC
Primary source
HGNC:HGNC:11089
See related
Ensembl:ENSG00000170290 MIM:602203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 82.3), esophagus (RPKM 53.1) and 2 other tissues See more
Orthologs

Genomic context

See SLN in Genome Data Viewer
Location:
11q22.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (107707378..107712056, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (107578101..107582787, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267904 Neighboring gene ELMO domain containing 1 Neighboring gene MOB-like protein phocein Neighboring gene sorting nexin 7 pseudogene Neighboring gene solute carrier family 35 member F2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12301, MGC125854, MGC125855

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enzyme inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcium ion transport NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of calcium ion import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of calcium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of protein complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of calcium-transporting ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of relaxation of muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcoplasmic reticulum calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003063.3NP_003054.1  sarcolipin

    See identical proteins and their annotated locations for NP_003054.1

    Status: REVIEWED

    Source sequence(s)
    AP002353, BC094685, BP233121
    Consensus CDS
    CCDS31667.1
    UniProtKB/Swiss-Prot
    O00631
    UniProtKB/TrEMBL
    A0A158RFT9
    Related
    ENSP00000304707.2, ENST00000305991.3
    Conserved Domains (1) summary
    pfam05366
    Location:131
    Sarcolipin; Sarcolipin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    107707378..107712056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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