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SLC22A2 solute carrier family 22 member 2 [ Homo sapiens (human) ]

Gene ID: 6582, updated on 11-Jul-2021

Summary

Official Symbol
SLC22A2provided by HGNC
Official Full Name
solute carrier family 22 member 2provided by HGNC
Primary source
HGNC:HGNC:10966
See related
Ensembl:ENSG00000112499 MIM:602608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCT2
Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward kidney (RPKM 70.1) See more
Orthologs
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Genomic context

See SLC22A2 in Genome Data Viewer
Location:
6q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (160216755..160258821, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160637787..160679853, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 1 Neighboring gene mitochondrial import receptor subunit TOM6 homolog pseudogene Neighboring gene uncharacterized LOC105378088 Neighboring gene solute carrier family 22 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Genetic loci influencing kidney function and chronic kidney disease.
GeneReviews: Not available
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Oct proteins have been shown to bind to HIV-1 Tat and both enhance and repress Tat-mediated transactivation of the HIV-1 LTR promoter, suggesting a role for Oct proteins in regulation of Tat function PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC32628

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables L-arginine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables amine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables choline transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neurotransmitter transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neurotransmitter transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables organic cation transmembrane transporter activity EXP
Inferred from Experiment
more info
PubMed 
enables organic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables organic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables organic cation transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables organic cation transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables pyrimidine nucleoside transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables toxin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables toxin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-arginine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amino acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in body fluid secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in choline transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dopamine uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histamine uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in neurotransmitter transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter transport TAS
Traceable Author Statement
more info
 
involved_in norepinephrine uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within organic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in purine-containing compound transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in pyrimidine-containing compound transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in serotonin uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toxin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
involved_in xenobiotic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 2
Names
organic cation transporter 2
solute carrier family 22 (organic cation transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003058.4NP_003049.2  solute carrier family 22 member 2

    See identical proteins and their annotated locations for NP_003049.2

    Status: REVIEWED

    Source sequence(s)
    AL162582
    Consensus CDS
    CCDS5276.1
    UniProtKB/Swiss-Prot
    O15244
    Related
    ENSP00000355920.3, ENST00000366953.8
    Conserved Domains (2) summary
    cd06174
    Location:124492
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:13525
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    160216755..160258821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153191.1: Suppressed sequence

    Description
    NM_153191.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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