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SLC22A3 solute carrier family 22 member 3 [ Homo sapiens (human) ]

Gene ID: 6581, updated on 22-Aug-2020

Summary

Official Symbol
SLC22A3provided by HGNC
Official Full Name
solute carrier family 22 member 3provided by HGNC
Primary source
HGNC:HGNC:10967
See related
Ensembl:ENSG00000146477 MIM:604842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMT; EMTH; OCT3
Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 29.4), prostate (RPKM 6.3) and 10 other tissues See more
Orthologs

Genomic context

See SLC22A3 in Genome Data Viewer
Location:
6q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (160348378..160454982)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160769405..160873613)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 2 Neighboring gene uncharacterized LOC105378088 Neighboring gene lipoprotein(a) like 2, pseudogene Neighboring gene lipoprotein(a)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.
GeneReviews: Not available
Genetic and clinical correlates of early-outgrowth colony-forming units.
GeneReviews: Not available
Genetic variants in PLG, LPA and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.
GeneReviews: Not available
Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.
GeneReviews: Not available
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
GeneReviews: Not available
Multiple newly identified loci associated with prostate cancer susceptibility.
GeneReviews: Not available
Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
GeneReviews: Not available
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
dopamine uptake IDA
Inferred from Direct Assay
more info
PubMed 
drug transmembrane transport TAS
Traceable Author Statement
more info
 
epinephrine uptake IDA
Inferred from Direct Assay
more info
PubMed 
histamine metabolic process TAS
Traceable Author Statement
more info
PubMed 
histamine uptake IDA
Inferred from Direct Assay
more info
PubMed 
histamine uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
monoamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter transport IDA
Inferred from Direct Assay
more info
PubMed 
norepinephrine uptake IDA
Inferred from Direct Assay
more info
PubMed 
organic anion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
organic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
quaternary ammonium group transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of appetite IEA
Inferred from Electronic Annotation
more info
 
serotonin uptake IDA
Inferred from Direct Assay
more info
PubMed 
toxin transport IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 3
Names
EMT organic cation transporter 3
extraneuronal monoamine transporter
organic cation transporter 3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
solute carrier family 22 (organic cation transporter), member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021977.4NP_068812.1  solute carrier family 22 member 3

    See identical proteins and their annotated locations for NP_068812.1

    Status: REVIEWED

    Source sequence(s)
    AF078749, AK314590
    Consensus CDS
    CCDS5277.1
    UniProtKB/Swiss-Prot
    O75751
    Related
    ENSP00000275300.2, ENST00000275300.3
    Conserved Domains (2) summary
    cd06174
    Location:149518
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12528
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    160348378..160454982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267107.3XP_005267164.1  solute carrier family 22 member 3 isoform X3

    Conserved Domains (2) summary
    cd06174
    Location:149289
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12327
    2A0119; cation transport protein
  2. XM_011536076.3XP_011534378.1  solute carrier family 22 member 3 isoform X2

    See identical proteins and their annotated locations for XP_011534378.1

    Conserved Domains (2) summary
    cd06174
    Location:4366
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:1376
    2A0119; cation transport protein
  3. XM_005267106.5XP_005267163.1  solute carrier family 22 member 3 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:18387
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:13397
    2A0119; cation transport protein
  4. XM_017011203.2XP_016866692.1  solute carrier family 22 member 3 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:4366
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:1376
    2A0119; cation transport protein
  5. XM_011536075.2XP_011534377.1  solute carrier family 22 member 3 isoform X2

    See identical proteins and their annotated locations for XP_011534377.1

    Conserved Domains (2) summary
    cd06174
    Location:4366
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:1376
    2A0119; cation transport protein

RNA

  1. XR_001743588.1 RNA Sequence

  2. XR_001743589.1 RNA Sequence

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