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SLC22A1 solute carrier family 22 member 1 [ Homo sapiens (human) ]

Gene ID: 6580, updated on 11-Apr-2024

Summary

Official Symbol
SLC22A1provided by HGNC
Official Full Name
solute carrier family 22 member 1provided by HGNC
Primary source
HGNC:HGNC:10963
See related
Ensembl:ENSG00000175003 MIM:602607; AllianceGenome:HGNC:10963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCT1; HOCT1; oct1_cds
Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 121.5) See more
Orthologs
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Genomic context

See SLC22A1 in Genome Data Viewer
Location:
6q25.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (160121815..160158718)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (161367910..161404908)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160542847..160579750)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene insulin like growth factor 2 receptor Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:160532738-160533326 Neighboring gene uncharacterized LOC124901452 Neighboring gene CHP1 pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:160554924-160556123 Neighboring gene mitochondrial import receptor subunit TOM6 homolog Neighboring gene MPRA-validated peak6287 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:160647818-160648746 Neighboring gene solute carrier family 22 member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160660268-160661163 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160661164-160662058

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide association study identifies new prostate cancer susceptibility loci.
EBI GWAS Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Oct proteins have been shown to bind to HIV-1 Tat and both enhance and repress Tat-mediated transactivation of the HIV-1 LTR promoter, suggesting a role for Oct proteins in regulation of Tat function PubMed
Vif vif HIV-1 Vif upregulates the expression of solute carrier family 22, member 1 (SLC22A1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables (R)-carnitine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables acetylcholine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dopamine:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables monoamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neurotransmitter transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables norepinephrine:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables organic cation transmembrane transporter activity EXP
Inferred from Experiment
more info
PubMed 
enables organic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables organic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables organic cation transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables prostaglandin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables putrescine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyrimidine nucleoside transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables quaternary ammonium group transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables secondary active organic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables spermidine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables thiamine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables toxin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables toxin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables xenobiotic transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in (R)-carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in acetylcholine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in acyl carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular detoxification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular detoxification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dopamine uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epinephrine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
involved_in metanephric proximal tubule development IEA
Inferred from Electronic Annotation
more info
 
involved_in monoamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in norepinephrine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in norepinephrine uptake IEA
Inferred from Electronic Annotation
more info
 
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in organic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic cation transport TAS
Traceable Author Statement
more info
PubMed 
involved_in prostaglandin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in purine-containing compound transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in putrescine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in quaternary ammonium group transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in serotonin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in serotonin uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in spermidine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in thiamine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thiamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
involved_in xenobiotic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane TAS
Traceable Author Statement
more info
 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 1
Names
organic cation transporter 1
solute carrier family 22 (organic cation transporter), member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003057.3NP_003048.1  solute carrier family 22 member 1 isoform a

    See identical proteins and their annotated locations for NP_003048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer and predominant transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AL353625
    Consensus CDS
    CCDS5274.1
    UniProtKB/Swiss-Prot
    A6NFF3, A8K1H2, C9JSU6, O15245, O15395, Q9NQD4
    Related
    ENSP00000355930.4, ENST00000366963.9
    Conserved Domains (2) summary
    cd06174
    Location:118514
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12524
    2A0119; cation transport protein
  2. NM_153187.2NP_694857.1  solute carrier family 22 member 1 isoform b

    See identical proteins and their annotated locations for NP_694857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL353625
    Consensus CDS
    CCDS5275.1
    UniProtKB/Swiss-Prot
    O15245
    Related
    ENSP00000318103.4, ENST00000324965.8
    Conserved Domains (2) summary
    cd06174
    Location:118465
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12465
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    160121815..160158718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267103.3XP_005267160.1  solute carrier family 22 member 1 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:118484
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12500
    2A0119; cation transport protein
  2. XM_006715552.3XP_006715615.1  solute carrier family 22 member 1 isoform X2

    UniProtKB/Swiss-Prot
    O15245
    Related
    ENSP00000409557.2, ENST00000457470.6
    Conserved Domains (2) summary
    cd06174
    Location:118462
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12462
    2A0119; cation transport protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    161367910..161404908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356250.1XP_054212225.1  solute carrier family 22 member 1 isoform X3

  2. XM_054356251.1XP_054212226.1  solute carrier family 22 member 1 isoform X4