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SLC22A1 solute carrier family 22 member 1 [ Homo sapiens (human) ]

Gene ID: 6580, updated on 17-Sep-2017
Official Symbol
SLC22A1provided by HGNC
Official Full Name
solute carrier family 22 member 1provided by HGNC
Primary source
HGNC:HGNC:10963
See related
Ensembl:ENSG00000175003 MIM:602607; Vega:OTTHUMG00000015947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCT1; HOCT1; oct1_cds
Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6q25.3
Exon count:
14
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (160121789..160159201)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160542821..160580147)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene insulin like growth factor 2 receptor Neighboring gene antisense of IGF2R non-protein coding RNA Neighboring gene calcineurin like EF-hand protein 1 pseudogene Neighboring gene solute carrier family 22 member 2 Neighboring gene uncharacterized LOC105378088

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association study identifies new prostate cancer susceptibility loci.
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Oct proteins have been shown to bind to HIV-1 Tat and both enhance and repress Tat-mediated transactivation of the HIV-1 LTR promoter, suggesting a role for Oct proteins in regulation of Tat function PubMed
Vif vif HIV-1 Vif upregulates the expression of solute carrier family 22, member 1 (SLC22A1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Abacavir transmembrane transport, organism-specific biosystem (from REACTOME)
    Abacavir transmembrane transport, organism-specific biosystemCytosolic levels of abacavir are determined by the balance of its facilitated diffusion into the cell mediated by organic cation transporters SLC22A1, 2, and 3, and its ATP-dependent efflux from cell...
  • Abacavir transport and metabolism, organism-specific biosystem (from REACTOME)
    Abacavir transport and metabolism, organism-specific biosystemAbacavir is a nucleoside analogue reverse transcriptase inhibitor with antiretroviral activity, widely used in combination with other drugs to treat HIV-1 infection (Yuen et al. 2008). Its uptake acr...
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
    Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Choline metabolism in cancer, conserved biosystem (from KEGG)
    Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Na+/Cl- dependent neurotransmitter transporters, organism-specific biosystem (from REACTOME)
    Na+/Cl- dependent neurotransmitter transporters, organism-specific biosystemThe SLC6 gene family encodes proteins that mediate neurotransmitter uptake thus terminating a synaptic signal. The proteins mediate transport of GABA (gamma-aminobutyric acid), norepinephrine, dopami...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Clearance In The Synaptic Cleft, organism-specific biosystem (from REACTOME)
    Neurotransmitter Clearance In The Synaptic Cleft, organism-specific biosystemNeurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synapti...
  • Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Neurotransmitter Release Cycle, organism-specific biosystemNeurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotr...
  • Norepinephrine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Norepinephrine Neurotransmitter Release Cycle, organism-specific biosystemNoradrenalin release cycle consists of reacidification of the empty clathrin sculpted monoamine transport vesicle, loading of dopamine into reacidified clathrin coated monamine transport vesicle, con...
  • Organic cation transport, organism-specific biosystem (from REACTOME)
    Organic cation transport, organism-specific biosystemThe organic cation transporters comprise three SLC22 members, OCT1-3. They can transport a wide range of organic cations including weak bases. All transport by OCTs is electrogenic, sodium-independen...
  • Organic cation/anion/zwitterion transport, organism-specific biosystem (from REACTOME)
    Organic cation/anion/zwitterion transport, organism-specific biosystemThe SLC22 gene family of solute carriers function as organic cation transporters (OCTs), cation/zwitterion transporters (OCTNs) and organic anion transporters (OATs). The SLC22 family belongs to the ...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystem (from REACTOME)
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystemHexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse acro...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylcholine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
dopamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
norepinephrine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
organic cation transmembrane transporter activity EXP
Inferred from Experiment
more info
PubMed 
organic cation transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
quaternary ammonium group transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
secondary active organic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acetate ester transport IEA
Inferred from Electronic Annotation
more info
 
ammonium transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
dopamine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
drug transmembrane transport TAS
Traceable Author Statement
more info
 
epinephrine transport IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter transport IBA
Inferred from Biological aspect of Ancestor
more info
 
norepinephrine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
organic anion transport IEA
Inferred from Electronic Annotation
more info
 
organic cation transport TAS
Traceable Author Statement
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
quaternary ammonium group transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
solute carrier family 22 member 1
Names
organic cation transporter 1
solute carrier family 22 (organic cation transporter), member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003057.2NP_003048.1  solute carrier family 22 member 1 isoform a

    See identical proteins and their annotated locations for NP_003048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer and predominant transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AV684761, X98332
    Consensus CDS
    CCDS5274.1
    UniProtKB/Swiss-Prot
    O15245
    Related
    ENSP00000355930.4, OTTHUMP00000017537, ENST00000366963.8, OTTHUMT00000042938
    Conserved Domains (2) summary
    cd06174
    Location:118514
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12524
    2A0119; cation transport protein
  2. NM_153187.1NP_694857.1  solute carrier family 22 member 1 isoform b

    See identical proteins and their annotated locations for NP_694857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AV684761, X98332
    Consensus CDS
    CCDS5275.1
    UniProtKB/Swiss-Prot
    O15245
    Related
    ENSP00000318103.4, OTTHUMP00000238993, ENST00000324965.8, OTTHUMT00000400154
    Conserved Domains (2) summary
    cd06174
    Location:118465
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12465
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

    Range
    160121789..160159201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267102.4XP_005267159.1  solute carrier family 22 member 1 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:118484
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12499
    2A0119; cation transport protein
  2. XM_005267103.1XP_005267160.1  solute carrier family 22 member 1 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:118484
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12500
    2A0119; cation transport protein
  3. XM_006715552.1XP_006715615.1  solute carrier family 22 member 1 isoform X3

    UniProtKB/Swiss-Prot
    O15245
    Related
    ENSP00000409557.2, OTTHUMP00000238994, ENST00000457470.6, OTTHUMT00000400155
    Conserved Domains (2) summary
    cd06174
    Location:118462
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12462
    2A0119; cation transport protein
  4. XM_005267105.4XP_005267162.1  solute carrier family 22 member 1 isoform X4

    See identical proteins and their annotated locations for XP_005267162.1

    Conserved Domains (1) summary
    cd06174
    Location:1292
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  5. XM_011536074.2XP_011534376.1  solute carrier family 22 member 1 isoform X4

    See identical proteins and their annotated locations for XP_011534376.1

    Conserved Domains (1) summary
    cd06174
    Location:1292
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  6. XM_005267104.4XP_005267161.1  solute carrier family 22 member 1 isoform X4

    See identical proteins and their annotated locations for XP_005267161.1

    Conserved Domains (1) summary
    cd06174
    Location:1292
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    160805108..160841995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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