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SLC20A2 solute carrier family 20 member 2 [ Homo sapiens (human) ]

Gene ID: 6575, updated on 29-Jan-2023

Summary

Official Symbol
SLC20A2provided by HGNC
Official Full Name
solute carrier family 20 member 2provided by HGNC
Primary source
HGNC:HGNC:10947
See related
Ensembl:ENSG00000168575 MIM:158378; AllianceGenome:HGNC:10947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIT2; RAM1; GLVR2; IBGC1; IBGC2; IBGC3; MLVAR; PIT-2; Ram-1; GLVR-2
Summary
This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in thyroid (RPKM 23.3), heart (RPKM 12.0) and 24 other tissues See more
Orthologs
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Genomic context

See SLC20A2 in Genome Data Viewer
Location:
8p11.21
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (42416475..42541954, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (42686790..42809936, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42273993..42397097, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene dickkopf WNT signaling pathway inhibitor 4 Neighboring gene voltage dependent anion channel 3 Neighboring gene Sharpr-MPRA regulatory region 15103 Neighboring gene Sharpr-MPRA regulatory region 9023 Neighboring gene small integral membrane protein 19 Neighboring gene Sharpr-MPRA regulatory region 2659

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inorganic phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables sodium:phosphate symporter activity TAS
Traceable Author Statement
more info
 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in monoatomic ion transport TAS
Traceable Author Statement
more info
 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium-dependent phosphate transporter 2
Names
epididymis secretory sperm binding protein
gibbon ape leukemia virus receptor 2
murine leukemia virus, amphotropic, receptor for
murine leukemia virus, amphotropic; receptor
solute carrier family 20 (phosphate transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032161.2 RefSeqGene

    Range
    45723..130479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257180.2NP_001244109.1  sodium-dependent phosphate transporter 2

    See identical proteins and their annotated locations for NP_001244109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK291202, BC028600, H10927
    Consensus CDS
    CCDS6132.1
    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
    Related
    ENSP00000429754.1, ENST00000520262.6
    Conserved Domains (2) summary
    COG0306
    Location:7224
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:491637
    PHO4; Phosphate transporter family
  2. NM_001257181.2NP_001244110.1  sodium-dependent phosphate transporter 2

    See identical proteins and their annotated locations for NP_001244110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK295952, AK314774, BC028600, H10927
    Consensus CDS
    CCDS6132.1
    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38, B2RBR4, B4DJ71
    Related
    ENSP00000429712.1, ENST00000520179.5
    Conserved Domains (2) summary
    COG0306
    Location:7224
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:491637
    PHO4; Phosphate transporter family
  3. NM_006749.5NP_006740.1  sodium-dependent phosphate transporter 2

    See identical proteins and their annotated locations for NP_006740.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC028600, DA418477, H10927, L20852
    Consensus CDS
    CCDS6132.1
    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
    Related
    ENSP00000340465.3, ENST00000342228.7
    Conserved Domains (2) summary
    COG0306
    Location:7224
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:491637
    PHO4; Phosphate transporter family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    42416475..42541954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447237.2XP_024303005.1  sodium-dependent phosphate transporter 2 isoform X2

    Conserved Domains (1) summary
    pfam01384
    Location:436590
    PHO4; Phosphate transporter family
  2. XM_017013748.2XP_016869237.1  sodium-dependent phosphate transporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
    Conserved Domains (2) summary
    COG0306
    Location:7224
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:491637
    PHO4; Phosphate transporter family
  3. XM_006716390.5XP_006716453.1  sodium-dependent phosphate transporter 2 isoform X2

    Conserved Domains (1) summary
    pfam01384
    Location:436590
    PHO4; Phosphate transporter family
  4. XM_005273613.4XP_005273670.1  sodium-dependent phosphate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_005273670.1

    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
    Conserved Domains (2) summary
    COG0306
    Location:7224
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:491637
    PHO4; Phosphate transporter family
  5. XM_024447235.2XP_024303003.1  sodium-dependent phosphate transporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
    Conserved Domains (2) summary
    COG0306
    Location:7224
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:491637
    PHO4; Phosphate transporter family
  6. XM_047422121.1XP_047278077.1  sodium-dependent phosphate transporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
  7. XM_047422124.1XP_047278080.1  sodium-dependent phosphate transporter 2 isoform X2

  8. XM_047422122.1XP_047278078.1  sodium-dependent phosphate transporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
  9. XM_047422123.1XP_047278079.1  sodium-dependent phosphate transporter 2 isoform X2

  10. XM_024447236.2XP_024303004.1  sodium-dependent phosphate transporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
    Conserved Domains (2) summary
    COG0306
    Location:7224
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:491637
    PHO4; Phosphate transporter family
  11. XM_017013749.3XP_016869238.1  sodium-dependent phosphate transporter 2 isoform X2

    Conserved Domains (1) summary
    pfam01384
    Location:436590
    PHO4; Phosphate transporter family
  12. XM_047422120.1XP_047278076.1  sodium-dependent phosphate transporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q08357
    UniProtKB/TrEMBL
    A0A384MR38
  13. XM_017013752.3XP_016869241.1  sodium-dependent phosphate transporter 2 isoform X3

    Conserved Domains (2) summary
    COG0306
    Location:349507
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:401499
    PHO4; Phosphate transporter family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    42686790..42809936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)