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SLC20A1 solute carrier family 20 member 1 [ Homo sapiens (human) ]

Gene ID: 6574, updated on 8-Jul-2018
Official Symbol
SLC20A1provided by HGNC
Official Full Name
solute carrier family 20 member 1provided by HGNC
Primary source
HGNC:HGNC:10946
See related
Ensembl:ENSG00000144136 MIM:137570; Vega:OTTHUMG00000131317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIT1; GLVR1; PiT-1; Glvr-1
Summary
The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 15.0), colon (RPKM 14.5) and 24 other tissues See more
Orthologs
See SLC20A1 in Genome Data Viewer
Location:
2q14.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (112645857..112663825)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113403434..113421402)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985934 Neighboring gene uncharacterized LOC400999 Neighboring gene uncharacterized LOC102724955 Neighboring gene 5'-nucleotidase domain containing 4 Neighboring gene cytoskeleton associated protein 2 like

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC20A1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ41426, DKFZp686J2397

Gene Ontology Provided by GOA

Function Evidence Code Pubs
high-affinity inorganic phosphate:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 
inorganic phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
sodium-dependent phosphate transmembrane transporter activity TAS
Traceable Author Statement
more info
 
sodium:inorganic phosphate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:phosphate symporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ion transport TAS
Traceable Author Statement
more info
 
phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphate-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium-dependent phosphate transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
sodium-dependent phosphate transporter 1
Names
gibbon ape leukemia virus receptor 1
leukemia virus receptor 1 homolog
solute carrier family 20 (phosphate transporter), member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028281.1 RefSeqGene

    Range
    5001..22969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005415.4NP_005406.3  sodium-dependent phosphate transporter 1

    See identical proteins and their annotated locations for NP_005406.3

    Status: REVIEWED

    Source sequence(s)
    AC079922, AK312738, BC075818, DB086768
    Consensus CDS
    CCDS2099.1
    UniProtKB/Swiss-Prot
    Q8WUM9
    UniProtKB/TrEMBL
    A7LNJ1
    Related
    ENSP00000272542.3, OTTHUMP00000161992, ENST00000272542.7, OTTHUMT00000254086
    Conserved Domains (2) summary
    COG0306
    Location:22240
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:519665
    PHO4; Phosphate transporter family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    112645857..112663825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004771.2XP_016860260.1  sodium-dependent phosphate transporter 1 isoform X2

    Conserved Domains (2) summary
    COG0306
    Location:251423
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:267411
    PHO4; Phosphate transporter family
  2. XM_017004770.2XP_016860259.1  sodium-dependent phosphate transporter 1 isoform X2

    Conserved Domains (2) summary
    COG0306
    Location:251423
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:267411
    PHO4; Phosphate transporter family
  3. XM_024453052.1XP_024308820.1  sodium-dependent phosphate transporter 1 isoform X1

    Conserved Domains (1) summary
    pfam01384
    Location:306452
    PHO4; Phosphate transporter family
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