U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC20A1 solute carrier family 20 member 1 [ Homo sapiens (human) ]

Gene ID: 6574, updated on 22-May-2022

Summary

Official Symbol
SLC20A1provided by HGNC
Official Full Name
solute carrier family 20 member 1provided by HGNC
Primary source
HGNC:HGNC:10946
See related
Ensembl:ENSG00000144136 MIM:137570; AllianceGenome:HGNC:10946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIT1; GLVR1; PiT-1; Glvr-1
Summary
The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 15.0), colon (RPKM 14.5) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLC20A1 in Genome Data Viewer
Location:
2q14.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (112645939..112663825)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113072544..113090428)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113403516..113421402)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14161 Neighboring gene SLC20A1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 7980 Neighboring gene uncharacterized LOC102724955 Neighboring gene 5'-nucleotidase domain containing 4 Neighboring gene cytoskeleton associated protein 2 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC20A1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41426, DKFZp686J2397

General protein information

Preferred Names
sodium-dependent phosphate transporter 1
Names
gibbon ape leukemia virus receptor 1
leukemia virus receptor 1 homolog
solute carrier family 20 (phosphate transporter), member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028281.1 RefSeqGene

    Range
    5083..22969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005415.5NP_005406.3  sodium-dependent phosphate transporter 1

    See identical proteins and their annotated locations for NP_005406.3

    Status: REVIEWED

    Source sequence(s)
    AC079922, AK312738, BC075818, DB086768
    Consensus CDS
    CCDS2099.1
    UniProtKB/Swiss-Prot
    Q8WUM9
    UniProtKB/TrEMBL
    A7LNJ1
    Related
    ENSP00000272542.3, ENST00000272542.8
    Conserved Domains (2) summary
    COG0306
    Location:22240
    PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
    pfam01384
    Location:519665
    PHO4; Phosphate transporter family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    112645939..112663825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    113072544..113090428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)