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SLC15A2 solute carrier family 15 member 2 [ Homo sapiens (human) ]

Gene ID: 6565, updated on 4-Oct-2020

Summary

Official Symbol
SLC15A2provided by HGNC
Official Full Name
solute carrier family 15 member 2provided by HGNC
Primary source
HGNC:HGNC:10921
See related
Ensembl:ENSG00000163406 MIM:602339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEPT2
Summary
The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]
Expression
Biased expression in prostate (RPKM 19.8), brain (RPKM 10.1) and 13 other tissues See more
Orthologs

Genomic context

See SLC15A2 in Genome Data Viewer
Location:
3q13.33
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (121894401..121944188)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (121613171..121663034)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene IQ motif containing B1 Neighboring gene ELL associated factor 2 Neighboring gene uncharacterized LOC101927010 Neighboring gene Sharpr-MPRA regulatory region 6303 Neighboring gene immunoglobulin like domain containing receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33407

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dipeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide:proton symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
dipeptide import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
dipeptide transport ISS
Inferred from Sequence or Structural Similarity
more info
 
drug transmembrane export NAS
Non-traceable Author Statement
more info
PubMed 
ion transport TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
renal absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
xenobiotic transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
spanning component of membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
spanning component of plasma membrane IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
solute carrier family 15 member 2
Names
kidney H(+)/peptide cotransporter
peptide transporter 2
solute carrier family 15 (H+/peptide transporter), member 2
solute carrier family 15 (oligopeptide transporter), member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145998.2NP_001139470.1  solute carrier family 15 member 2 isoform b

    See identical proteins and their annotated locations for NP_001139470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC072031
    Consensus CDS
    CCDS54631.1
    UniProtKB/Swiss-Prot
    Q16348
    Related
    ENSP00000295605.2, ENST00000295605.6
    Conserved Domains (2) summary
    TIGR00926
    Location:58665
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
    pfam00854
    Location:114450
    PTR2; POT family
  2. NM_021082.4NP_066568.3  solute carrier family 15 member 2 isoform a

    See identical proteins and their annotated locations for NP_066568.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC072031
    Consensus CDS
    CCDS3007.1
    UniProtKB/Swiss-Prot
    Q16348
    Related
    ENSP00000417085.1, ENST00000489711.6
    Conserved Domains (2) summary
    TIGR00926
    Location:58696
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
    pfam00854
    Location:111481
    PTR2; POT family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    121894401..121944188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247722.3XP_005247779.1  solute carrier family 15 member 2 isoform X1

    Conserved Domains (2) summary
    TIGR00926
    Location:58661
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
    pfam00854
    Location:111481
    PTR2; POT family
  2. XM_006713736.3XP_006713799.1  solute carrier family 15 member 2 isoform X2

    Conserved Domains (1) summary
    pfam00854
    Location:111481
    PTR2; POT family
  3. XM_017007074.1XP_016862563.1  solute carrier family 15 member 2 isoform X3

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