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SLC15A2 solute carrier family 15 member 2 [ Homo sapiens (human) ]

Gene ID: 6565, updated on 9-Dec-2024

Summary

Official Symbol
SLC15A2provided by HGNC
Official Full Name
solute carrier family 15 member 2provided by HGNC
Primary source
HGNC:HGNC:10921
See related
Ensembl:ENSG00000163406 MIM:602339; AllianceGenome:HGNC:10921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEPT2
Summary
The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]
Expression
Biased expression in prostate (RPKM 19.8), brain (RPKM 10.1) and 13 other tissues See more
Orthologs
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Genomic context

See SLC15A2 in Genome Data Viewer
Location:
3q13.33
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (121894401..121944188)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (124614370..124664153)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (121613248..121663035)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20349 Neighboring gene IQ motif containing B1 Neighboring gene ELL associated factor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:121611674-121612207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:121612208-121612740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:121657363-121657943 Neighboring gene uncharacterized LOC101927010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:121711615-121712116 Neighboring gene Sharpr-MPRA regulatory region 6303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20352 Neighboring gene NANOG hESC enhancer GRCh37_chr3:121724759-121725260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20354 Neighboring gene immunoglobulin like domain containing receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20363 Neighboring gene CD86 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14639

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ33407

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dipeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide:proton symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide:proton symporter activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tripeptide transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in antibacterial innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dipeptide import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dipeptide import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dipeptide transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monoatomic ion transport TAS
Traceable Author Statement
more info
 
involved_in peptidoglycan transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in renal absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
involved_in tripeptide import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
involved_in xenobiotic transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
is_active_in phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 15 member 2
Names
kidney H(+)/peptide cotransporter
peptide transporter 2
solute carrier family 15 (H+/peptide transporter), member 2
solute carrier family 15 (oligopeptide transporter), member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145998.2NP_001139470.1  solute carrier family 15 member 2 isoform b

    See identical proteins and their annotated locations for NP_001139470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC072031
    Consensus CDS
    CCDS54631.1
    UniProtKB/TrEMBL
    B4DXJ3
    Related
    ENSP00000295605.2, ENST00000295605.6
    Conserved Domains (2) summary
    TIGR00926
    Location:58665
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
    pfam00854
    Location:114450
    PTR2; POT family
  2. NM_021082.4NP_066568.3  solute carrier family 15 member 2 isoform a

    See identical proteins and their annotated locations for NP_066568.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC072031
    Consensus CDS
    CCDS3007.1
    UniProtKB/Swiss-Prot
    A8K1A5, B4E2A7, Q16348
    UniProtKB/TrEMBL
    Q86UE9
    Related
    ENSP00000417085.1, ENST00000489711.6
    Conserved Domains (1) summary
    TIGR00926
    Location:58696
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    121894401..121944188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247722.4XP_005247779.1  solute carrier family 15 member 2 isoform X1

    UniProtKB/TrEMBL
    Q86UE9
    Conserved Domains (2) summary
    TIGR00926
    Location:58661
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
    pfam00854
    Location:111481
    PTR2; POT family
  2. XM_006713736.4XP_006713799.1  solute carrier family 15 member 2 isoform X2

    Conserved Domains (1) summary
    pfam00854
    Location:111481
    PTR2; POT family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    124614370..124664153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347623.1XP_054203598.1  solute carrier family 15 member 2 isoform X1

    UniProtKB/TrEMBL
    Q86UE9
  2. XM_054347624.1XP_054203599.1  solute carrier family 15 member 2 isoform X2