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SLC10A1 solute carrier family 10 member 1 [ Homo sapiens (human) ]

Gene ID: 6554, updated on 7-Jun-2020

Summary

Official Symbol
SLC10A1provided by HGNC
Official Full Name
solute carrier family 10 member 1provided by HGNC
Primary source
HGNC:HGNC:10905
See related
Ensembl:ENSG00000100652 MIM:182396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTCP
Summary
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
Expression
Restricted expression toward liver (RPKM 124.7) See more
Orthologs

Genomic context

See SLC10A1 in Genome Data Viewer
Location:
14q24.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (69775416..69797241, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70242552..70264006, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene sushi domain containing 6 Neighboring gene Sharpr-MPRA regulatory region 8327 Neighboring gene uncharacterized LOC100289511 Neighboring gene Sharpr-MPRA regulatory region 10266 Neighboring gene serine and arginine rich splicing factor 5 Neighboring gene uncharacterized LOC100506358 Neighboring gene ribosomal protein L7a pseudogene 6 Neighboring gene SPARC related modular calcium binding 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (SLC10A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bile acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bile acid:sodium symporter activity TAS
Traceable Author Statement
more info
 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/bile acid cotransporter
Names
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Na/taurocholate cotransporting polypeptide
cell growth-inhibiting gene 29 protein
growth-inhibiting protein 29
sodium/taurocholate cotransporter
sodium/taurocholate cotransporting polypeptide
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
solute carrier family 10 (sodium/bile acid cotransporter), member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003049.4NP_003040.1  sodium/bile acid cotransporter

    See identical proteins and their annotated locations for NP_003040.1

    Status: REVIEWED

    Source sequence(s)
    AK314028, AL157789, BC069799, L21893
    Consensus CDS
    CCDS9797.1
    UniProtKB/Swiss-Prot
    Q14973
    UniProtKB/TrEMBL
    B2RA41
    Related
    ENSP00000216540.4, ENST00000216540.5
    Conserved Domains (1) summary
    TIGR00841
    Location:22311
    bass; bile acid transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    69775416..69797241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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