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BMP7 bone morphogenetic protein 7 [ Homo sapiens (human) ]

Gene ID: 655, updated on 23-Jun-2022

Summary

Official Symbol
BMP7provided by HGNC
Official Full Name
bone morphogenetic protein 7provided by HGNC
Primary source
HGNC:HGNC:1074
See related
Ensembl:ENSG00000101144 MIM:112267; AllianceGenome:HGNC:1074
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OP-1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
Expression
Biased expression in thyroid (RPKM 30.0), placenta (RPKM 15.8) and 9 other tissues See more
Orthologs
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Genomic context

See BMP7 in Genome Data Viewer
Location:
20q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (57168753..57266641, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (58946552..59044382, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (55743809..55841697, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372685 Neighboring gene VISTA enhancer hs2565 Neighboring gene uncharacterized LOC105372686 Neighboring gene BMP7 antisense RNA 1 Neighboring gene BMP7 promoter region Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC105372687 Neighboring gene microRNA 4325 Neighboring gene ribosomal protein L39 pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genomewide association study of citalopram response in major depressive disorder.
EBI GWAS Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 reduces osteoblast function and significantly decreases the levels of BMP-7 and RANK-L PubMed
Pr55(Gag) gag HIV-1 Gag reduces osteoblast function and significantly reduces the levels of BMP-2, BMP-7, osteocalcin, and RANK-L PubMed
Tat tat Treatment of pulmonary arterial smooth muscle cells with HIV-1 Tat induces significantly higher secretion of BMP-2 and BMP-7 ligands when compared with that of untreated cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables BMP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in allantois development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ameloblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cartilage development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to BMP stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chorio-allantoic fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendrite development TAS
Traceable Author Statement
more info
PubMed 
involved_in embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic skeletal joint morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial to mesenchymal transition TAS
Traceable Author Statement
more info
PubMed 
involved_in heart trabecula morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hindbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mesenchymal cell apoptotic process involved in nephron morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mesenchyme development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
involved_in mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric mesenchymal cell proliferation involved in metanephros development IEA
Inferred from Electronic Annotation
more info
 
involved_in metanephric mesenchyme morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in metanephros development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in monocyte aggregation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of NIK/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glomerular mesangial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of prostatic bud formation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of striated muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nephrogenic mesenchyme morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in neural fold elevation formation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in pericardium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pharyngeal system development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendrite development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of hyaluranon cable assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of branching involved in prostate gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of removal of superoxide radicals ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal system development TAS
Traceable Author Statement
more info
PubMed 
involved_in steroid hormone mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ureteric bud development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bone morphogenetic protein 7
Names
osteogenic protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032771.1 RefSeqGene

    Range
    5011..102899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001719.3NP_001710.1  bone morphogenetic protein 7 preproprotein

    See identical proteins and their annotated locations for NP_001710.1

    Status: REVIEWED

    Source sequence(s)
    AK291186, AL157414, BM683430, DA740733
    Consensus CDS
    CCDS13455.1
    UniProtKB/Swiss-Prot
    P18075
    UniProtKB/TrEMBL
    A8K571
    Related
    ENSP00000379204.3, ENST00000395863.8
    Conserved Domains (2) summary
    pfam00688
    Location:35280
    TGFb_propeptide; TGF-beta propeptide
    cd19397
    Location:325431
    TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    57168753..57266641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    58946552..59044382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)