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SLC9A2 solute carrier family 9 member A2 [ Homo sapiens (human) ]

Gene ID: 6549, updated on 13-Mar-2020

Summary

Official Symbol
SLC9A2provided by HGNC
Official Full Name
solute carrier family 9 member A2provided by HGNC
Primary source
HGNC:HGNC:11072
See related
Ensembl:ENSG00000115616 MIM:600530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHE2
Summary
This gene encodes a member of the sodium-hydrogen exchanger (NHE) protein family. These proteins are involved in sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and help in the regulation of cell pH and volume. The encoded protein is localized to the apical membrane and is involved in apical absorption of sodium. [provided by RefSeq, Jun 2016]
Expression
Biased expression in stomach (RPKM 13.9), colon (RPKM 13.0) and 10 other tissues See more
Orthologs

Genomic context

See SLC9A2 in Genome Data Viewer
Location:
2q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (102619553..102711355)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (103236166..103327809)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 18 receptor accessory protein Neighboring gene microRNA 4772 Neighboring gene solute carrier family 9 member A4 Neighboring gene major facilitator superfamily domain containing 9 Neighboring gene transmembrane protein 182

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef EIPA, a potent and specific inhibitor of Na+/H+ exchanger activity, significantly inhibits the Nef internalization into M2-macrophages, indicating that Nef is imported by Na+/H+ exchanger (solute carrier family 9, subfamily A) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization IEA
Inferred from Electronic Annotation
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/hydrogen exchanger 2
Names
Na(+)/H(+) exchanger 2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050930.1 RefSeqGene

    Range
    5020..96822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003048.6NP_003039.2  sodium/hydrogen exchanger 2 precursor

    See identical proteins and their annotated locations for NP_003039.2

    Status: REVIEWED

    Source sequence(s)
    AA843986, AC007239, AF273748, BC035787, BC136377
    Consensus CDS
    CCDS2062.1
    UniProtKB/Swiss-Prot
    Q9UBY0
    Related
    ENSP00000233969.2, ENST00000233969.3
    Conserved Domains (3) summary
    TIGR00840
    Location:74630
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:84484
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    pfam16644
    Location:579684
    NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    102619553..102711355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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