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FER1L6 fer-1 like family member 6 [ Homo sapiens (human) ]

Gene ID: 654463, updated on 5-Jan-2022

Summary

Official Symbol
FER1L6provided by HGNC
Official Full Name
fer-1 like family member 6provided by HGNC
Primary source
HGNC:HGNC:28065
See related
Ensembl:ENSG00000214814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8ORFK23
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in plasma membrane organization. Predicted to act upstream of or within response to bacterium. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in stomach (RPKM 17.6), colon (RPKM 3.5) and 5 other tissues See more
Orthologs
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Genomic context

See FER1L6 in Genome Data Viewer
Location:
8q24.13
Exon count:
47
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (123851987..124120061)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124864227..125132302)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375739 Neighboring gene annexin A13 Neighboring gene family with sequence similarity 91 member A1 Neighboring gene FER1L6 antisense RNA 1 Neighboring gene FER1L6 antisense RNA 2 Neighboring gene neuropilin and tolloid like 2 pseudogene Neighboring gene ADP ribosylation factor 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in plasma membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fer-1-like protein 6
Names
fer-1-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039112.2NP_001034201.2  fer-1-like protein 6

    See identical proteins and their annotated locations for NP_001034201.2

    Status: VALIDATED

    Source sequence(s)
    AB196633, AC011134, AC100871, DV080599, DW010047
    Consensus CDS
    CCDS43767.1
    UniProtKB/Swiss-Prot
    Q2WGJ9
    Related
    ENSP00000428280.1, ENST00000522917.5
    Conserved Domains (8) summary
    cd04011
    Location:80189
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:826959
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:244395
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:13571480
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:15971730
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:713784
    FerB; FerB (NUC096) domain
    pfam08151
    Location:187236
    FerI; FerI (NUC094) domain
    pfam16165
    Location:17411850
    Ferlin_C; Ferlin C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    123851987..124120061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517235.3XP_011515537.1  fer-1-like protein 6 isoform X4

    Conserved Domains (7) summary
    cd04011
    Location:103212
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:849982
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:267418
    C2C_Ferlin; C2 domain third repeat in Ferlin
    pfam05103
    Location:628734
    DivIVA; DivIVA protein
    pfam08150
    Location:736807
    FerB; FerB (NUC096) domain
    pfam08151
    Location:210259
    FerI; FerI (NUC094) domain
    cl14603
    Location:13801437
    C2; C2 domain
  2. XM_011517231.2XP_011515533.1  fer-1-like protein 6 isoform X1

    Conserved Domains (8) summary
    cd04011
    Location:103212
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:849982
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:267418
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:13801503
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:16201753
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:736807
    FerB; FerB (NUC096) domain
    pfam08151
    Location:210259
    FerI; FerI (NUC094) domain
    pfam16165
    Location:17641873
    Ferlin_C; Ferlin C-terminus
  3. XM_006716618.3XP_006716681.1  fer-1-like protein 6 isoform X2

    Conserved Domains (8) summary
    cd04011
    Location:90199
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:836969
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:254405
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:13671490
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:16071740
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:723794
    FerB; FerB (NUC096) domain
    pfam08151
    Location:197246
    FerI; FerI (NUC094) domain
    pfam16165
    Location:17511860
    Ferlin_C; Ferlin C-terminus
  4. XM_011517232.3XP_011515534.1  fer-1-like protein 6 isoform X3

    See identical proteins and their annotated locations for XP_011515534.1

    UniProtKB/Swiss-Prot
    Q2WGJ9
    Conserved Domains (8) summary
    cd04011
    Location:80189
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:826959
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:244395
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:13571480
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:15971730
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:713784
    FerB; FerB (NUC096) domain
    pfam08151
    Location:187236
    FerI; FerI (NUC094) domain
    pfam16165
    Location:17411850
    Ferlin_C; Ferlin C-terminus
  5. XM_011517233.3XP_011515535.1  fer-1-like protein 6 isoform X3

    See identical proteins and their annotated locations for XP_011515535.1

    UniProtKB/Swiss-Prot
    Q2WGJ9
    Conserved Domains (8) summary
    cd04011
    Location:80189
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:826959
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:244395
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:13571480
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:15971730
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:713784
    FerB; FerB (NUC096) domain
    pfam08151
    Location:187236
    FerI; FerI (NUC094) domain
    pfam16165
    Location:17411850
    Ferlin_C; Ferlin C-terminus
  6. XM_011517236.2XP_011515538.1  fer-1-like protein 6 isoform X5

    Conserved Domains (4) summary
    cd04017
    Location:499
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04037
    Location:497620
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:737870
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam16165
    Location:881990
    Ferlin_C; Ferlin C-terminus

RNA

  1. XR_928347.2 RNA Sequence

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