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LRTM2 leucine rich repeats and transmembrane domains 2 [ Homo sapiens (human) ]

Gene ID: 654429, updated on 21-Dec-2019

Summary

Official Symbol
LRTM2provided by HGNC
Official Full Name
leucine rich repeats and transmembrane domains 2provided by HGNC
Primary source
HGNC:HGNC:32443
See related
Ensembl:ENSG00000166159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward brain (RPKM 3.3) See more
Orthologs

Genomic context

See LRTM2 in Genome Data Viewer
Location:
12p13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (1820267..1836753)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1929433..1945919)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene uncharacterized LOC105369602 Neighboring gene Sharpr-MPRA regulatory region 5038 Neighboring gene uncharacterized LOC105369601 Neighboring gene lysosomal associated membrane protein 1 pseudogene 1 Neighboring gene uncharacterized LOC112268103

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Clone Names

  • FLJ42697

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat and transmembrane domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039029.3NP_001034118.1  leucine-rich repeat and transmembrane domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001034118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC005343, AK095610, BC036868, BX115405, DA336140, DA418133
    Consensus CDS
    CCDS31726.1
    UniProtKB/Swiss-Prot
    Q8N967
    Related
    ENSP00000299194.1, ENST00000299194.6
    Conserved Domains (6) summary
    TIGR00864
    Location:174261
    PCC; polycystin cation channel protein
    smart00013
    Location:3970
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:5172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:92152
    LRR_8; Leucine rich repeat
    cl26018
    Location:57202
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl27544
    Location:265335
    Herpes_glycop_D; Herpesvirus glycoprotein D/GG/GX domain
  2. NM_001163925.1NP_001157397.1  leucine-rich repeat and transmembrane domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001157397.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK095610, AK124687, BC036868, BX115405, DA336140
    Consensus CDS
    CCDS31726.1
    UniProtKB/Swiss-Prot
    Q8N967
    Related
    ENSP00000446278.1, ENST00000543818.5
    Conserved Domains (6) summary
    TIGR00864
    Location:174261
    PCC; polycystin cation channel protein
    smart00013
    Location:3970
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:5172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:92152
    LRR_8; Leucine rich repeat
    cl26018
    Location:57202
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl27544
    Location:265335
    Herpes_glycop_D; Herpesvirus glycoprotein D/GG/GX domain
  3. NM_001163926.2NP_001157398.1  leucine-rich repeat and transmembrane domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001157398.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC005343, AK095610, BC146894, BX115405, DA336140
    Consensus CDS
    CCDS31726.1
    UniProtKB/Swiss-Prot
    Q8N967
    Related
    ENSP00000444737.1, ENST00000535041.5
    Conserved Domains (6) summary
    TIGR00864
    Location:174261
    PCC; polycystin cation channel protein
    smart00013
    Location:3970
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:5172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:92152
    LRR_8; Leucine rich repeat
    cl26018
    Location:57202
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl27544
    Location:265335
    Herpes_glycop_D; Herpesvirus glycoprotein D/GG/GX domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    1820267..1836753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521015.1XP_011519317.1  leucine-rich repeat and transmembrane domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011519317.1

    UniProtKB/Swiss-Prot
    Q8N967
    Conserved Domains (6) summary
    TIGR00864
    Location:174261
    PCC; polycystin cation channel protein
    smart00013
    Location:3970
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:5172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:92152
    LRR_8; Leucine rich repeat
    cl26018
    Location:57202
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl27544
    Location:265335
    Herpes_glycop_D; Herpesvirus glycoprotein D/GG/GX domain
  2. XM_017019848.1XP_016875337.1  leucine-rich repeat and transmembrane domain-containing protein 2 isoform X1

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654718.1 Reference GRCh38.p13 PATCHES

    Range
    162411..178897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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