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OCM oncomodulin [ Homo sapiens (human) ]

Gene ID: 654231, updated on 25-Jan-2022

Summary

Official Symbol
OCMprovided by HGNC
Official Full Name
oncomodulinprovided by HGNC
Primary source
HGNC:HGNC:8105
See related
Ensembl:ENSG00000122543 MIM:164795; AllianceGenome:HGNC:8105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OM; OCM1; ONCM
Summary
Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq, Jul 2008]
Annotation information
Note: There are two oncomodulin-like loci on chromosome 7 (GeneIDs 4951 and 654231). The nomenclature for the p and q arm locations was modified to agree with reports (including PMID: 1559707) that place the OCM gene on the p arm. [18 Jun 2007]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OCM in Genome Data Viewer
Location:
7p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (5859718..5886363)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5920429..5925994)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ring finger protein 216 Neighboring gene microRNA 6874 Neighboring gene zinc finger protein 815, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 556, pseudogene Neighboring gene nonconserved acetylation island sequence 61 enhancer Neighboring gene uncharacterized LOC107986694 Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC97453, MGC97465, MGC97477, MGC142264, MGC142266

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
oncomodulin-1
Names
beta parvalbumin
hCG18255
parvalbumin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097622.2NP_001091091.1  oncomodulin-1 isoform a

    See identical proteins and their annotated locations for NP_001091091.1

    Status: VALIDATED

    Source sequence(s)
    BC113704, CB045979, DB339645
    Consensus CDS
    CCDS43548.1
    UniProtKB/Swiss-Prot
    P0CE72
    Related
    ENSP00000242104.5, ENST00000242104.6
    Conserved Domains (1) summary
    cd16255
    Location:9109
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin
  2. NM_001391990.1NP_001378919.1  oncomodulin-1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004983
    Conserved Domains (1) summary
    cd16255
    Location:9109
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin
  3. NM_001391991.1NP_001378920.1  oncomodulin-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004983
    Conserved Domains (2) summary
    cd16251
    Location:534
    EFh_parvalbumin_like; EF-hand motif [structural motif]
    cl25356
    Location:171
    EFh_parvalbumin_like; EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    5859718..5886363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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