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LOC6541174 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [ Drosophila erecta ]

Gene ID: 6541174, updated on 21-Dec-2023

Summary

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Gene symbol
LOC6541174
Gene description
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Locus tag
Dere_GG23962
See related
EnsemblRapid:LOC6541174
Gene type
protein coding
RefSeq status
MODEL
Organism
Drosophila erecta
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Pten; GG23962; GG23962-PB; GG23962-PD; GG23962-PF
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Genomic context

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Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
101 current DereRS2 (GCF_003286155.1) Unplaced Scaffold NW_020825200.1 (11132328..11137040, complement)

NW_020825200.1Genomic Context describing neighboring genes Neighboring gene tyrosine-protein kinase transmembrane receptor Ror Neighboring gene FUN14 domain-containing protein 2 Neighboring gene RNA-binding protein Rsf1 Neighboring gene REPTOR-binding partner

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020825200 Unplaced Scaffold Reference DereRS2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Network-level molecular evolutionary analysis of the insulin/TOR signal transduction pathway across 12 Drosophila genomes. Alvarez-Ponce D, et al. Genome Res, 2009 Feb. PMID 19141596, Free PMC Article
  2. Evolution of genes and genomes on the Drosophila phylogeny. Drosophila 12 Genomes Consortium, et al. Nature, 2007 Nov 8. PMID 17994087

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Names
Dere\GG23962
Dere\GG23962-PB
Dere\GG23962-PD
Dere\GG23962-PF
dere_GLEANR_8735

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Drosophila erecta Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference DereRS2

Genomic

  1. NW_020825200.1 Reference DereRS2

    Range
    11132328..11137040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_026978991.1 → XP_026834792.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

    UniProtKB/TrEMBL
    B3N951
    Related
    XP_026834792.1, XM_026978991.1
    Conserved Domains (2) summary
    pfam10409
    Location:195 → 335
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl25998
    Location:95 → 186
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

  2. XM_015159499.2 → XP_015014985.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2

    UniProtKB/TrEMBL
    A0A0Q5WAE1
    Related
    XP_015014985.1, XM_015159499.2
    Conserved Domains (2) summary
    pfam10409
    Location:195 → 335
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21483
    Location:62 → 167
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

  1. XR_001448618.2 RNA Sequence

    Related
    XR_001448618.2
Nucleotide Protein
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