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ACTR3C actin related protein 3C [ Homo sapiens (human) ]

Gene ID: 653857, updated on 2-Nov-2024

Summary

Official Symbol
ACTR3Cprovided by HGNC
Official Full Name
actin related protein 3Cprovided by HGNC
Primary source
HGNC:HGNC:37282
See related
Ensembl:ENSG00000106526 AllianceGenome:HGNC:37282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP11
Summary
Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 1.0), adrenal (RPKM 0.6) and 25 other tissues See more
Orthologs
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Genomic context

See ACTR3C in Genome Data Viewer
Location:
7q36.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149881360..150323545, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151063321..151501798, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149578449..150020634, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552405-149552958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552959-149553510 Neighboring gene ATP6V0E2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149570857-149571825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18770 Neighboring gene zinc finger protein 862 Neighboring gene ATPase H+ transporting V0 subunit e2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:149604113-149604612 Neighboring gene uncharacterized LOC124901772 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:149697909-149698096 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149721691-149722215 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149728774-149729275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149732655-149733170 Neighboring gene uncharacterized LOC100134040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149745856-149746490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149746491-149747124 Neighboring gene Sharpr-MPRA regulatory region 3139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149917438-149917972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149917973-149918507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149966003-149966503 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149976749-149977333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149983589-149984090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149984091-149984590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26822 Neighboring gene Sharpr-MPRA regulatory region 1750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18774 Neighboring gene leucine rich repeat containing 61 Neighboring gene zinc finger BED-type containing 10, pseudogene Neighboring gene retinoic acid receptor responder 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
actin-related protein 3C
Names
ARP3 actin related protein 3 homolog C
actin-related Arp11
actin-related protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164458.2NP_001157930.1  actin-related protein 3C isoform a precursor

    See identical proteins and their annotated locations for NP_001157930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 2, encodes the longest isoform (a).
    Source sequence(s)
    AB039791, BM674900, DA868104, DN992136, DR004860
    Consensus CDS
    CCDS47744.1
    UniProtKB/Swiss-Prot
    Q5CZI4, Q9C0K3
    UniProtKB/TrEMBL
    A0A0A0MTI9
    Related
    ENSP00000507618.1, ENST00000683684.1
    Conserved Domains (1) summary
    cl25542
    Location:1188
    Actin; Actin
  2. NM_001164459.2NP_001157931.1  actin-related protein 3C isoform a precursor

    See identical proteins and their annotated locations for NP_001157931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
    Source sequence(s)
    AB039791, AC005586, BM674900
    Consensus CDS
    CCDS47744.1
    UniProtKB/Swiss-Prot
    Q5CZI4, Q9C0K3
    UniProtKB/TrEMBL
    A0A0A0MTI9
    Related
    ENSP00000252071.4, ENST00000252071.8
    Conserved Domains (1) summary
    cl25542
    Location:1188
    Actin; Actin
  3. NM_001351027.2NP_001337956.1  actin-related protein 3C isoform b

    Status: VALIDATED

    Source sequence(s)
    AC092666, AC092681, AC093458
    Conserved Domains (1) summary
    PTZ00280
    Location:19117
    PTZ00280; Actin-related protein 3; Provisional
  4. NM_001351028.2NP_001337957.1  actin-related protein 3C isoform c

    Status: VALIDATED

    Source sequence(s)
    AC005586, AC092681, AC093458
    Conserved Domains (1) summary
    cl25542
    Location:9107
    Actin
  5. NM_001351029.2NP_001337958.1  actin-related protein 3C isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform d.
    Source sequence(s)
    AC006008, AC092681, AC093458
    Conserved Domains (1) summary
    cl25542
    Location:2059
    Actin
  6. NM_001351030.2NP_001337959.1  actin-related protein 3C isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform d.
    Source sequence(s)
    AC006008, AC092681, AC093458
    Conserved Domains (1) summary
    cl25542
    Location:2059
    Actin

RNA

  1. NR_147012.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005586, AC006008, AC092681, AC093458
  2. NR_147013.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005586, AC006008
    Related
    ENST00000478393.5
  3. NR_147014.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006008, AC092681, AC093458
  4. NR_147015.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006008, AC092681, AC093458
  5. NR_147016.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006008, AC092681, AC093458
  6. NR_147017.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006008, AC092681, AC093458
  7. NR_147018.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006008, AC092681, AC093458
  8. NR_147019.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006008, AC092681, AC093458
  9. NR_147020.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092666, AC092681, AC093458
  10. NR_147021.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092666, AC092681, AC093458
  11. NR_147022.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092666, AC092681, AC093458

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149881360..150323545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420750.1XP_047276706.1  actin-related protein 3C isoform X6

    Conserved Domains (1) summary
    PTZ00280
    Location:19117
    PTZ00280; Actin-related protein 3; Provisional
  2. XM_024446884.2XP_024302652.1  actin-related protein 3C isoform X6

    Conserved Domains (1) summary
    PTZ00280
    Location:19117
    PTZ00280; Actin-related protein 3; Provisional
  3. XM_047420751.1XP_047276707.1  actin-related protein 3C isoform X6

    Conserved Domains (1) summary
    PTZ00280
    Location:19117
    PTZ00280; Actin-related protein 3; Provisional
  4. XM_047420749.1XP_047276705.1  actin-related protein 3C isoform X4

    Related
    ENSP00000440990.2, ENST00000539352.5
  5. XM_047420748.1XP_047276704.1  actin-related protein 3C isoform X1

  6. XM_011516508.3XP_011514810.1  actin-related protein 3C isoform X2

    See identical proteins and their annotated locations for XP_011514810.1

    UniProtKB/Swiss-Prot
    Q5CZI4, Q9C0K3
    UniProtKB/TrEMBL
    A0A0A0MTI9
    Conserved Domains (1) summary
    cl25542
    Location:1188
    Actin; Actin
  7. XM_011516507.3XP_011514809.1  actin-related protein 3C isoform X2

    See identical proteins and their annotated locations for XP_011514809.1

    UniProtKB/Swiss-Prot
    Q5CZI4, Q9C0K3
    UniProtKB/TrEMBL
    A0A0A0MTI9
    Conserved Domains (1) summary
    cl25542
    Location:1188
    Actin; Actin
  8. XM_011516506.4XP_011514808.1  actin-related protein 3C isoform X2

    See identical proteins and their annotated locations for XP_011514808.1

    UniProtKB/Swiss-Prot
    Q5CZI4, Q9C0K3
    UniProtKB/TrEMBL
    A0A0A0MTI9
    Conserved Domains (1) summary
    cl25542
    Location:1188
    Actin; Actin
  9. XM_005250043.5XP_005250100.3  actin-related protein 3C isoform X3

    UniProtKB/TrEMBL
    A0A0A0MTI9
    Conserved Domains (1) summary
    cl17037
    Location:1188
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  10. XM_011516511.4XP_011514813.1  actin-related protein 3C isoform X5

    UniProtKB/TrEMBL
    A0A0A0MTI9
    Conserved Domains (1) summary
    cl17037
    Location:1190
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. XR_007060145.1 RNA Sequence

  2. XR_007060143.1 RNA Sequence

  3. XR_007060144.1 RNA Sequence

  4. XR_007060142.1 RNA Sequence

  5. XR_007060141.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151063321..151501798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)