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FAM72B family with sequence similarity 72 member B [ Homo sapiens (human) ]

Gene ID: 653820, updated on 13-May-2022

Summary

Official Symbol
FAM72Bprovided by HGNC
Official Full Name
family with sequence similarity 72 member Bprovided by HGNC
Primary source
HGNC:HGNC:24805
See related
Ensembl:ENSG00000188610 MIM:614711; AllianceGenome:HGNC:24805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p17
Summary
Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 6.0), appendix (RPKM 3.2) and 17 other tissues See more
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Genomic context

See FAM72B in Genome Data Viewer
Location:
1p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (121167646..121184340, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (121177006..121193704, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120838983..120855681)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3 histone pseudogene 4 Neighboring gene H2B histone pseudogene 1 Neighboring gene ribosomal protein L22 pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 3361 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2C Neighboring gene Sharpr-MPRA regulatory region 15698 duplicate 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
protein FAM72B
Names
RP11-439A17.6
amyloid-beta peptide-induced protein p17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100910.2NP_001094380.1  protein FAM72B isoform 1

    See identical proteins and their annotated locations for NP_001094380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC244453
    Consensus CDS
    CCDS72848.1
    UniProtKB/Swiss-Prot
    Q86X60
    Related
    ENSP00000358397.3, ENST00000369390.7
    Conserved Domains (1) summary
    pfam14976
    Location:6149
    FAM72; FAM72 protein
  2. NM_001320149.2NP_001307078.1  protein FAM72B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC244453
    Consensus CDS
    CCDS81362.1
    UniProtKB/Swiss-Prot
    Q86X60
    Related
    ENSP00000347368.4, ENST00000355228.8
    Conserved Domains (1) summary
    pfam14976
    Location:11109
    FAM72; FAM72 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    121167646..121184340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    121177006..121193704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)