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GSTT2B glutathione S-transferase theta 2B [ Homo sapiens (human) ]

Gene ID: 653689, updated on 6-Sep-2022

Summary

Official Symbol
GSTT2Bprovided by HGNC
Official Full Name
glutathione S-transferase theta 2Bprovided by HGNC
Primary source
HGNC:HGNC:33437
See related
Ensembl:ENSG00000133433 AllianceGenome:HGNC:33437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSTT2P
Summary
The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Broad expression in adrenal (RPKM 23.9), skin (RPKM 19.2) and 21 other tissues See more
Orthologs
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Genomic context

See GSTT2B in Genome Data Viewer
Location:
22q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23957414..23961206, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24299601..24303393, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 5 pseudogene Neighboring gene glutathione S-transferase theta-4-like Neighboring gene D-dopachrome tautomerase like Neighboring gene D-dopachrome tautomerase Neighboring gene glutathione S-transferase theta 2 (gene/pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC744, MGC87963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
glutathione S-transferase theta-2B
Names
GST class-theta-2
glutathione S-transferase theta 2
NP_001074312.1
NP_001350733.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080843.4NP_001074312.1  glutathione S-transferase theta-2B isoform 1

    See identical proteins and their annotated locations for NP_001074312.1

    Status: VALIDATED

    Source sequence(s)
    AC253536
    Consensus CDS
    CCDS33617.1
    UniProtKB/Swiss-Prot
    P0CG30
    UniProtKB/TrEMBL
    G9J6Q5
    Related
    ENSP00000290765.4, ENST00000290765.9
    Conserved Domains (2) summary
    cd03183
    Location:91216
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cd03050
    Location:378
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
  2. NM_001363804.1NP_001350733.1  glutathione S-transferase theta-2B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC253536
    Consensus CDS
    CCDS87010.1
    UniProtKB/TrEMBL
    Q6ICJ4
    Related
    ENSP00000385116.3, ENST00000404172.3
    Conserved Domains (2) summary
    cd03183
    Location:91202
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cd03050
    Location:378
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    23957414..23961206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    193776..197568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)