U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PPIAL4C peptidylprolyl isomerase A like 4C [ Homo sapiens (human) ]

Gene ID: 653598, updated on 23-Nov-2023

Summary

Official Symbol
PPIAL4Cprovided by HGNC
Official Full Name
peptidylprolyl isomerase A like 4Cprovided by HGNC
Primary source
HGNC:HGNC:33995
See related
Ensembl:ENSG00000288867 AllianceGenome:HGNC:33995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COAS-2
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PPIAL4C in Genome Data Viewer
Location:
1q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149583848..149584607)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148707993..148708752)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149553028..149553787)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NBPF member 19 Neighboring gene uncharacterized LOC101060227 Neighboring gene tRNA-Asn (anticodon GTT) 25-1 Neighboring gene uncharacterized LOC124904410 Neighboring gene uncharacterized LOC124904409 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:147931672-147932203 Neighboring gene long intergenic non-protein coding RNA 869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1652 Neighboring gene RNA, variant U1 small nuclear 30

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ16804, MGC163248, MGC163250

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase A-like 4A/B/C
Names
PPIase A-like 4A
PPIase A-like 4C
chromosome 1-amplified sequence 2
chromosome one-amplified sequence 2
cyclophilin homolog overexpressed in liver cancer
peptidylprolyl isomerase A (cyclophilin A)-like 4C
NP_001129261.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135789.5NP_001129261.2  peptidyl-prolyl cis-trans isomerase A-like 4A/B/C

    See identical proteins and their annotated locations for NP_001129261.2

    Status: VALIDATED

    Source sequence(s)
    AC242842
    Consensus CDS
    CCDS72898.1
    UniProtKB/Swiss-Prot
    A0A0B4J2A2, A1L431, A2BFH1
    UniProtKB/TrEMBL
    A0A0H2UH34
    Related
    ENSP00000463057.2, ENST00000585245.3
    Conserved Domains (1) summary
    cl00197
    Location:4162
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    149583848..149584607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    148707993..148708752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)