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PHLDB3 pleckstrin homology like domain family B member 3 [ Homo sapiens (human) ]

Gene ID: 653583, updated on 23-Nov-2021

Summary

Official Symbol
PHLDB3provided by HGNC
Official Full Name
pleckstrin homology like domain family B member 3provided by HGNC
Primary source
HGNC:HGNC:30499
See related
Ensembl:ENSG00000176531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 4.9), skin (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

See PHLDB3 in Genome Data Viewer
Location:
19q13.31
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43474341..43504916, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43979255..44008898, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene testis expressed 101 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene LY6/PLAUR domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 2471 Neighboring gene ETHE1 persulfide dioxygenase Neighboring gene zinc finger protein 575

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40193, MGC87511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology-like domain family B member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198850.4NP_942147.3  pleckstrin homology-like domain family B member 3

    See identical proteins and their annotated locations for NP_942147.3

    Status: VALIDATED

    Source sequence(s)
    AA621318, BC007947, BC029299, BG403419, BU858992, CA502903, CB850627
    Consensus CDS
    CCDS12621.2
    UniProtKB/Swiss-Prot
    Q6NSJ2
    UniProtKB/TrEMBL
    Q96HZ0
    Related
    ENSP00000292140.5, ENST00000292140.9
    Conserved Domains (2) summary
    cd14673
    Location:535635
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:535630
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43474341..43504916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527236.3XP_011525538.1  pleckstrin homology-like domain family B member 3 isoform X1

    See identical proteins and their annotated locations for XP_011525538.1

    Conserved Domains (2) summary
    cd14673
    Location:530630
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:530625
    PH; PH domain
  2. XM_005259170.4XP_005259227.1  pleckstrin homology-like domain family B member 3 isoform X2

    Conserved Domains (2) summary
    cd14673
    Location:496596
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:496591
    PH; PH domain
  3. XM_005259169.4XP_005259226.1  pleckstrin homology-like domain family B member 3 isoform X1

    See identical proteins and their annotated locations for XP_005259226.1

    Conserved Domains (2) summary
    cd14673
    Location:530630
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:530625
    PH; PH domain
  4. XM_005259171.4XP_005259228.1  pleckstrin homology-like domain family B member 3 isoform X3

    Conserved Domains (1) summary
    TIGR02168
    Location:111319
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_243954.4 RNA Sequence

  2. XR_430208.4 RNA Sequence

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