U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR89A G protein-coupled receptor 89A [ Homo sapiens (human) ]

Gene ID: 653519, updated on 22-Sep-2022

Summary

Official Symbol
GPR89Aprovided by HGNC
Official Full Name
G protein-coupled receptor 89Aprovided by HGNC
Primary source
HGNC:HGNC:31984
See related
Ensembl:ENSG00000117262 MIM:612821; AllianceGenome:HGNC:31984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPHR; GPR89; SH120; GPR89B; UNQ192
Summary
GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]
Annotation information
Note: There are multiple copies of the sequence G protein-coupled receptor 89 in the human genome. After consultation with the HUGO Gene Nomenclature committee, the symbol GPR89A was assigned to the most centromeric locus. [06 Jun 2007]
Expression
Ubiquitous expression in kidney (RPKM 15.4), testis (RPKM 12.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GPR89A in Genome Data Viewer
Location:
1q21.1
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145607988..145670650)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144724765..144787440)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145764409..145827075, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PDE4DIP pseudogene 5 Neighboring gene NBPF member 25, pseudogene Neighboring gene PDZ domain containing 1 Neighboring gene CD160 molecule Neighboring gene ring finger protein 115

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC688, FLJ10492, FLJ11696, FLJ36909, FLJ79270, MGC87324

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables voltage-gated anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated anion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular pH reduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular pH reduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi cisterna membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi-associated vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Golgi pH regulator A
Names
protein GPR89
putative MAPK-activating protein PM01
putative NF-kappa-B-activating protein 90

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097612.2NP_001091081.1  Golgi pH regulator A isoform 1

    See identical proteins and their annotated locations for NP_001091081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB097025, AC242845, BC003187, DC349534
    Consensus CDS
    CCDS72857.1
    UniProtKB/Swiss-Prot
    B7ZAQ6, P0CG08, Q9Y302
    UniProtKB/TrEMBL
    X5D7G6
    Related
    ENSP00000319673.9, ENST00000313835.14
    Conserved Domains (2) summary
    pfam12430
    Location:276446
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:140207
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  2. NM_001097613.3NP_001091082.2  Golgi pH regulator A isoform 2

    See identical proteins and their annotated locations for NP_001091082.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC242845, AK297145, AK316371, BC003187
    Consensus CDS
    CCDS72858.1
    UniProtKB/Swiss-Prot
    B7ZAQ6
    Related
    ENSP00000434495.1, ENST00000534502.5
    Conserved Domains (2) summary
    pfam12430
    Location:251419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

RNA

  1. NR_036541.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC242845, AK021758, AK297145, BC003187
    Related
    ENST00000460277.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    145607988..145670650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509908.3XP_011508210.1  Golgi pH regulator A isoform X2

    See identical proteins and their annotated locations for XP_011508210.1

    UniProtKB/Swiss-Prot
    B7ZAQ6
    Conserved Domains (2) summary
    pfam12430
    Location:251419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  2. XM_006711492.5XP_006711555.1  Golgi pH regulator A isoform X1

    See identical proteins and their annotated locations for XP_006711555.1

    UniProtKB/Swiss-Prot
    B7ZAQ6, P0CG08, Q9Y302
    UniProtKB/TrEMBL
    X5D7G6
    Conserved Domains (2) summary
    pfam12430
    Location:276446
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:140207
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  3. XM_047428710.1XP_047284666.1  Golgi pH regulator A isoform X4

  4. XM_017002150.3XP_016857639.1  Golgi pH regulator A isoform X5

    Related
    ENSP00000433482.1, ENST00000466593.5
  5. XM_011509909.3XP_011508211.1  Golgi pH regulator A isoform X2

    See identical proteins and their annotated locations for XP_011508211.1

    UniProtKB/Swiss-Prot
    B7ZAQ6
    Related
    ENSP00000432248.1, ENST00000462900.2
    Conserved Domains (2) summary
    pfam12430
    Location:251419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  6. XM_047428704.1XP_047284660.1  Golgi pH regulator A isoform X3

RNA

  1. XR_007063066.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    144724765..144787440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)