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RGPD3 RANBP2 like and GRIP domain containing 3 [ Homo sapiens (human) ]

Gene ID: 653489, updated on 24-Nov-2020

Summary

Official Symbol
RGPD3provided by HGNC
Official Full Name
RANBP2 like and GRIP domain containing 3provided by HGNC
Primary source
HGNC:HGNC:32416
See related
Ensembl:ENSG00000153165 MIM:612706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP3
Summary
This gene is located in a cluster of Ran-binding protein related genes on chromosome 2 which arose through duplication in primates. The encoded protein contains an N-terminal TPR (tetratricopeptide repeat) domain, two Ran-binding domains, and a C-terminal GRIP domain (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain. [provided by RefSeq, Sep 2011]
Expression
Broad expression in testis (RPKM 22.2), thyroid (RPKM 6.7) and 25 other tissues See more

Genomic context

See RGPD3 in Genome Data Viewer
Location:
2q12.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (106403406..106470935, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (107021136..107084801, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ANAPC1 pseudogene 6 Neighboring gene plasminogen like A (pseudogene) Neighboring gene uncharacterized LOC105373534 Neighboring gene anaphase-promoting complex subunit 1-like Neighboring gene CD8b2 molecule Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ranBP2-like and GRIP domain-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021160.1 RefSeqGene

    Range
    5001..68666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144013.2NP_001137485.1  ranBP2-like and GRIP domain-containing protein 3

    See identical proteins and their annotated locations for NP_001137485.1

    Status: REVIEWED

    Source sequence(s)
    AC097527, AC114755
    Consensus CDS
    CCDS46379.1
    UniProtKB/Swiss-Prot
    A6NKT7
    Related
    ENSP00000386588.3, ENST00000409886.3
    Conserved Domains (8) summary
    COG5171
    Location:9761168
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10521168
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13491465
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6092
    TPR_1; Tetratricopeptide repeat
    pfam01465
    Location:17081750
    GRIP; GRIP domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
    pfam16704
    Location:16421706
    Rab_bind; Rab binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    106403406..106470935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004738.1XP_016860227.1  ranBP2-like and GRIP domain-containing protein 3 isoform X1

  2. XM_017004739.2XP_016860228.1  ranBP2-like and GRIP domain-containing protein 3 isoform X2

  3. XM_017004740.2XP_016860229.1  ranBP2-like and GRIP domain-containing protein 3 isoform X3

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