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CFC1B cripto, FRL-1, cryptic family 1B [ Homo sapiens (human) ]

Gene ID: 653275, updated on 8-Dec-2022

Summary

Official Symbol
CFC1Bprovided by HGNC
Official Full Name
cripto, FRL-1, cryptic family 1Bprovided by HGNC
Primary source
HGNC:HGNC:33983
See related
Ensembl:ENSG00000152093 AllianceGenome:HGNC:33983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable activin receptor binding activity and nodal binding activity. Predicted to be involved in several processes, including circulatory system development; determination of left/right symmetry; and nodal signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; digestive tract morphogenesis; and endoderm development. Predicted to be active in cell surface and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach (RPKM 4.2), prostate (RPKM 2.9) and 2 other tissues See more
Orthologs
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Genomic context

See CFC1B in Genome Data Viewer
Location:
2q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130521222..130528603)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (131026077..131033458, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131278795..131286176)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily F member 62, pseudogene Neighboring gene POTE ankyrin domain family member I Neighboring gene RNA, U6 small nuclear 473, pseudogene Neighboring gene serine protease 40B (pseudogene) Neighboring gene serine protease 40A (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gastrulation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079530.2NP_001072998.1  cryptic family protein 1B precursor

    See identical proteins and their annotated locations for NP_001072998.1

    Status: VALIDATED

    Source sequence(s)
    AC013269, BM716751, BQ777283, BU784123
    Consensus CDS
    CCDS33286.1
    UniProtKB/Swiss-Prot
    P0CG36, Q9GZR3
    Related
    ENSP00000281882.3, ENST00000281882.8
    Conserved Domains (2) summary
    cd00054
    Location:91115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam09443
    Location:123157
    CFC; Cripto_Frl-1_Cryptic (CFC)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    130521222..130528603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    131026077..131033458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)