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POTEI POTE ankyrin domain family member I [ Homo sapiens (human) ]

Gene ID: 653269, updated on 5-Jan-2022

Summary

Official Symbol
POTEIprovided by HGNC
Official Full Name
POTE ankyrin domain family member Iprovided by HGNC
Primary source
HGNC:HGNC:37093
See related
Ensembl:ENSG00000196834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POTE2beta
Summary
Involved in retina homeostasis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 2.9), prostate (RPKM 1.4) and 3 other tissues See more
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Genomic context

See POTEI in Genome Data Viewer
Location:
2q21.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (130459455..130509707, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131217028..131267280, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fatty acyl-CoA reductase 2 pseudogene 2 Neighboring gene Kruppel like factor 2 pseudogene 2 Neighboring gene cytochrome P450 family 4 subfamily F member 62, pseudogene Neighboring gene RNA, U6 small nuclear 473, pseudogene Neighboring gene cripto, FRL-1, cryptic family 1B Neighboring gene serine protease 40B (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
POTE ankyrin domain family member I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277406.2NP_001264335.1  POTE ankyrin domain family member I isoform 2

    See identical proteins and their annotated locations for NP_001264335.1

    Status: VALIDATED

    Source sequence(s)
    AC013269, AC132479
    Consensus CDS
    CCDS59431.1
    UniProtKB/Swiss-Prot
    P0CG38
    Related
    ENSP00000392718.2, ENST00000451531.7
    Conserved Domains (5) summary
    TIGR00927
    Location:370607
    2A1904; K+-dependent Na+/Ca+ exchanger
    sd00045
    Location:238269
    ANK; ANK repeat [structural motif]
    pfam14915
    Location:648701
    CCDC144C; CCDC144C protein coiled-coil region
    cl17037
    Location:7011075
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    cl39094
    Location:158361
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001371926.1NP_001358855.1  POTE ankyrin domain family member I isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC013269, AC132479
    Conserved Domains (4) summary
    sd00045
    Location:238269
    ANK; ANK repeat [structural motif]
    pfam14915
    Location:670723
    CCDC144C; CCDC144C protein coiled-coil region
    cl17037
    Location:7231097
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    cl39094
    Location:158361
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    130459455..130509707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453046.1XP_024308814.1  POTE ankyrin domain family member I isoform X2

    Conserved Domains (5) summary
    TIGR00927
    Location:370607
    2A1904; K+-dependent Na+/Ca+ exchanger
    sd00045
    Location:238269
    ANK; ANK repeat [structural motif]
    pfam14915
    Location:648701
    CCDC144C; CCDC144C protein coiled-coil region
    cl17037
    Location:7011075
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    cl39094
    Location:158361
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_017004732.2XP_016860221.1  POTE ankyrin domain family member I isoform X1

    Conserved Domains (5) summary
    smart00268
    Location:7151085
    ACTIN; Actin
    cd00204
    Location:167302
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:253345
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:248279
    ANK; ANK repeat [structural motif]
    cl17037
    Location:7111085
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_011511670.2XP_011509972.1  POTE ankyrin domain family member I isoform X1

    Conserved Domains (5) summary
    smart00268
    Location:7151085
    ACTIN; Actin
    cd00204
    Location:167302
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:253345
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:248279
    ANK; ANK repeat [structural motif]
    cl17037
    Location:7111085
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_017004733.1XP_016860222.1  POTE ankyrin domain family member I isoform X3

  5. XM_017004734.2XP_016860223.1  POTE ankyrin domain family member I isoform X4

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