Format

Send to:

Choose Destination

XAGE1B X antigen family member 1B [ Homo sapiens (human) ]

Gene ID: 653067, updated on 7-Aug-2021

Summary

Official Symbol
XAGE1Bprovided by HGNC
Official Full Name
X antigen family member 1Bprovided by HGNC
Primary source
HGNC:HGNC:25400
See related
Ensembl:ENSG00000204382 MIM:300289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTP9; XAGE1; CT12.1; GAGED2; XAGE-1; XAGE1C; XAGE1D; XAGE1E; CT12.1C; CT12.1D; CT12.1E; CT12.1b
Summary
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Annotation information
Note: There are two XAGE1 loci on the X chromosome. This location, previously annotated as XAGE1E, is now annotated as XAGE1B. [01 Dec 2017]
Expression
Restricted expression toward testis (RPKM 23.6) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See XAGE1B in Genome Data Viewer
Location:
Xp11.22
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (52512074..52517068, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52541053..52546197, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X antigen family member 1A Neighboring gene RNA binding motif protein 22 pseudogene 7 Neighboring gene RNA binding motif protein 22 pseudogene 11 Neighboring gene X antigen family member 5-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
X antigen family member 1
Names
G antigen family D member 2
X antigen family member 1E
X antigen family, member 1C
X antigen family, member 1D
cancer/testis antigen 12.1
cancer/testis antigen family 12, member 1b
cancer/testis antigen family 12, member 1c
cancer/testis antigen family 12, member 1d
cancer/testis antigen family 12, member 1e
cancer/testis associated protein
protein XAGE-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029951.2 RefSeqGene

    Range
    4968..10112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001097604.3NP_001091073.2  X antigen family member 1 isoform a

    See identical proteins and their annotated locations for NP_001091073.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a, also known as XAGE-1b) encodes the longer isoform (a, also known as isoform XAGE-1b).
    Source sequence(s)
    BX510359
    Consensus CDS
    CCDS48126.2
    UniProtKB/Swiss-Prot
    Q9HD64
    Related
    ENSP00000364766.1, ENST00000375616.5
    Conserved Domains (1) summary
    pfam05831
    Location:5575
    GAGE; GAGE protein
  2. NM_001097605.2NP_001091074.1  X antigen family member 1 isoform d

    See identical proteins and their annotated locations for NP_001091074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d, also known as XAGE-1d) starts at a downstream transcription start site, and uses an alternate splice site in an internal exon that causes a frameshift in the 3' coding region, compared to variant a. The encoded isoform (d) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    BX510359
    Consensus CDS
    CCDS48128.1
    UniProtKB/Swiss-Prot
    Q9HD64
    Related
    ENSP00000364763.3, ENST00000375613.7

RNA

  1. NR_033257.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c, also known as XAGE-1c) differs in the 5'-most exon, compared to variant a. This variant is represented as non-coding due to the presence of two upstream ORFs that inhibit translation of the primary ORF, as indicated by experimental evidence in PMID:17335148.
    Source sequence(s)
    BX510359
    Related
    ENST00000375612.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    52512074..52517068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029746.1XP_016885235.1  X antigen family member 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001097597.2: Suppressed sequence

    Description
    NM_001097597.2: This RefSeq was permanently suppressed because it is a redundant RefSeq for this XAGE1 family member.
  2. NM_001097598.2: Suppressed sequence

    Description
    NM_001097598.2: This RefSeq was permanently suppressed because it is a redundant RefSeq for this XAGE1 family member.
  3. NM_001097602.1: Suppressed sequence

    Description
    NM_001097602.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  4. NM_001097603.1: Suppressed sequence

    Description
    NM_001097603.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  5. NM_020411.2: Suppressed sequence

    Description
    NM_020411.2: This RefSeq was permanently suppressed because it is a redundant RefSeq for this XAGE1 family member.
  6. NM_133430.2: Suppressed sequence

    Description
    NM_133430.2: This RefSeq was permanently suppressed because it is a redundant RefSeq for this XAGE1 family member.
  7. NM_133431.3: Suppressed sequence

    Description
    NM_133431.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Support Center