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CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 [ Homo sapiens (human) ]

Gene ID: 652968, updated on 8-Jul-2021

Summary

Official Symbol
CASTOR1provided by HGNC
Official Full Name
cytosolic arginine sensor for mTORC1 subunit 1provided by HGNC
Primary source
HGNC:HGNC:34423
See related
Ensembl:ENSG00000239282 MIM:617034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GATSL3
Expression
Broad expression in esophagus (RPKM 13.7), placenta (RPKM 8.5) and 22 other tissues See more
Orthologs
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Genomic context

See CASTOR1 in Genome Data Viewer
Location:
22q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (30285117..30289505, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30681106..30685494, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene LIF antisense RNA 2 Neighboring gene LIF interleukin 6 family cytokine Neighboring gene oncostatin M Neighboring gene TBC1 domain family member 10A Neighboring gene origin of replication in TBC1D10A Neighboring gene splicing factor 3a subunit 1 Neighboring gene coiled-coil domain containing 157

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arginine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arginine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to L-arginine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to L-arginine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytosolic arginine sensor for mTORC1 subunit 1
Names
GATS protein like 3
GATS-like protein 3
cellular arginine sensor for mTORC1 protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037666.3NP_001032755.1  cytosolic arginine sensor for mTORC1 subunit 1

    See identical proteins and their annotated locations for NP_001032755.1

    Status: VALIDATED

    Source sequence(s)
    AC004997, BC021927, DA343534
    Consensus CDS
    CCDS43001.1
    UniProtKB/Swiss-Prot
    Q8WTX7
    Related
    ENSP00000384183.4, ENST00000407689.8
    Conserved Domains (2) summary
    pfam13840
    Location:258322
    ACT_7; ACT domain
    pfam18700
    Location:969
    Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    30285117..30289505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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