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WNK2 WNK lysine deficient protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 65268, updated on 5-Aug-2022

Summary

Official Symbol
WNK2provided by HGNC
Official Full Name
WNK lysine deficient protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:14542
See related
Ensembl:ENSG00000165238 MIM:606249; AllianceGenome:HGNC:14542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13
Summary
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in heart (RPKM 6.5), colon (RPKM 6.3) and 18 other tissues See more
Orthologs
NEW
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Genomic context

See WNK2 in Genome Data Viewer
Location:
9q22.31
Exon count:
34
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (93184139..93320569)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (105350754..105487952)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95946421..96082851)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902212 Neighboring gene Sharpr-MPRA regulatory region 13679 Neighboring gene uncharacterized LOC124902213 Neighboring gene uncharacterized LOC124902214 Neighboring gene family with sequence similarity 120A2, pseudogene Neighboring gene RNA, U6 small nuclear 829, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1760

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chloride channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase WNK2
Names
antigen NY-CO-43
mitogen-activated protein kinase kinase kinase
protein kinase lysine-deficient 2
protein kinase with no lysine 2
serologically defined colon cancer antigen 43
NP_001269323.1
NP_006639.3
XP_005252194.1
XP_005252197.1
XP_005252201.1
XP_016870534.1
XP_016870536.1
XP_016870537.1
XP_016870538.1
XP_016870539.1
XP_016870540.1
XP_016870541.1
XP_016870542.1
XP_016870543.1
XP_016870544.1
XP_047279697.1
XP_047279698.1
XP_047279699.1
XP_047279700.1
XP_047279701.1
XP_047279702.1
XP_047279703.1
XP_047279704.1
XP_047279705.1
XP_047279706.1
XP_047279707.1
XP_047279708.1
XP_047279709.1
XP_047279710.1
XP_047279712.1
XP_047279713.1
XP_047279714.1
XP_047279715.1
XP_047279716.1
XP_047279717.1
XP_047279718.1
XP_047279719.1
XP_047279720.1
XP_047279721.1
XP_047279723.1
XP_047279724.1
XP_047279725.1
XP_047279726.1
XP_047279727.1
XP_047279728.1
XP_047279729.1
XP_047279730.1
XP_047279731.1
XP_047279732.1
XP_047279734.1
XP_047279735.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282394.3NP_001269323.1  serine/threonine-protein kinase WNK2 isoform 1

    See identical proteins and their annotated locations for NP_001269323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL354991, AL390760, AL583839
    Consensus CDS
    CCDS75858.1
    UniProtKB/Swiss-Prot
    Q9H3P4, Q9Y3S1
    Related
    ENSP00000297954.4, ENST00000297954.9
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. NM_006648.4NP_006639.3  serine/threonine-protein kinase WNK2 isoform 2

    See identical proteins and their annotated locations for NP_006639.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL354991, AL390760, AL583839
    UniProtKB/TrEMBL
    F8W9F9
    Related
    ENSP00000411181.4, ENST00000427277.7
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    93184139..93320569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423745.1XP_047279701.1  serine/threonine-protein kinase WNK2 isoform X16

  2. XM_047423751.1XP_047279707.1  serine/threonine-protein kinase WNK2 isoform X22

  3. XM_047423761.1XP_047279717.1  serine/threonine-protein kinase WNK2 isoform X33

  4. XM_047423767.1XP_047279723.1  serine/threonine-protein kinase WNK2 isoform X38

  5. XM_047423754.1XP_047279710.1  serine/threonine-protein kinase WNK2 isoform X27

  6. XM_047423741.1XP_047279697.1  serine/threonine-protein kinase WNK2 isoform X8

  7. XM_047423747.1XP_047279703.1  serine/threonine-protein kinase WNK2 isoform X18

  8. XM_047423752.1XP_047279708.1  serine/threonine-protein kinase WNK2 isoform X23

  9. XM_047423762.1XP_047279718.1  serine/threonine-protein kinase WNK2 isoform X34

  10. XM_047423768.1XP_047279724.1  serine/threonine-protein kinase WNK2 isoform X39

  11. XM_047423753.1XP_047279709.1  serine/threonine-protein kinase WNK2 isoform X24

  12. XM_047423756.1XP_047279712.1  serine/threonine-protein kinase WNK2 isoform X28

  13. XM_047423770.1XP_047279726.1  serine/threonine-protein kinase WNK2 isoform X41

  14. XM_047423771.1XP_047279727.1  serine/threonine-protein kinase WNK2 isoform X42

  15. XM_005252137.4XP_005252194.1  serine/threonine-protein kinase WNK2 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  16. XM_005252140.3XP_005252197.1  serine/threonine-protein kinase WNK2 isoform X7

    UniProtKB/Swiss-Prot
    Q9Y3S1
    Related
    ENSP00000415038.2, ENST00000432730.6
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  17. XM_017015049.2XP_016870538.1  serine/threonine-protein kinase WNK2 isoform X5

  18. XM_047423742.1XP_047279698.1  serine/threonine-protein kinase WNK2 isoform X10

  19. XM_047423749.1XP_047279705.1  serine/threonine-protein kinase WNK2 isoform X20

  20. XM_017015054.2XP_016870543.1  serine/threonine-protein kinase WNK2 isoform X25

  21. XM_047423757.1XP_047279713.1  serine/threonine-protein kinase WNK2 isoform X29

  22. XM_047423764.1XP_047279720.1  serine/threonine-protein kinase WNK2 isoform X36

  23. XM_017015047.2XP_016870536.1  serine/threonine-protein kinase WNK2 isoform X3

  24. XM_017015052.2XP_016870541.1  serine/threonine-protein kinase WNK2 isoform X12

  25. XM_047423744.1XP_047279700.1  serine/threonine-protein kinase WNK2 isoform X14

  26. XM_017015045.2XP_016870534.1  serine/threonine-protein kinase WNK2 isoform X2

  27. XM_017015050.2XP_016870539.1  serine/threonine-protein kinase WNK2 isoform X6

  28. XM_047423743.1XP_047279699.1  serine/threonine-protein kinase WNK2 isoform X11

  29. XM_047423750.1XP_047279706.1  serine/threonine-protein kinase WNK2 isoform X21

  30. XM_017015055.2XP_016870544.1  serine/threonine-protein kinase WNK2 isoform X26

  31. XM_047423758.1XP_047279714.1  serine/threonine-protein kinase WNK2 isoform X30

  32. XM_047423765.1XP_047279721.1  serine/threonine-protein kinase WNK2 isoform X37

  33. XM_017015048.2XP_016870537.1  serine/threonine-protein kinase WNK2 isoform X4

  34. XM_017015053.2XP_016870542.1  serine/threonine-protein kinase WNK2 isoform X13

  35. XM_017015051.2XP_016870540.1  serine/threonine-protein kinase WNK2 isoform X9

  36. XM_047423748.1XP_047279704.1  serine/threonine-protein kinase WNK2 isoform X19

  37. XM_005252144.3XP_005252201.1  serine/threonine-protein kinase WNK2 isoform X15

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  38. XM_047423759.1XP_047279715.1  serine/threonine-protein kinase WNK2 isoform X31

  39. XM_047423769.1XP_047279725.1  serine/threonine-protein kinase WNK2 isoform X40

  40. XM_047423763.1XP_047279719.1  serine/threonine-protein kinase WNK2 isoform X35

  41. XM_047423746.1XP_047279702.1  serine/threonine-protein kinase WNK2 isoform X17

  42. XM_047423760.1XP_047279716.1  serine/threonine-protein kinase WNK2 isoform X32

  43. XM_047423773.1XP_047279729.1  serine/threonine-protein kinase WNK2 isoform X44

  44. XM_047423778.1XP_047279734.1  serine/threonine-protein kinase WNK2 isoform X48

  45. XM_047423774.1XP_047279730.1  serine/threonine-protein kinase WNK2 isoform X45

  46. XM_047423775.1XP_047279731.1  serine/threonine-protein kinase WNK2 isoform X46

    Related
    ENSP00000414622.1, ENST00000411624.5
  47. XM_047423772.1XP_047279728.1  serine/threonine-protein kinase WNK2 isoform X43

  48. XM_047423776.1XP_047279732.1  serine/threonine-protein kinase WNK2 isoform X47

  49. XM_047423779.1XP_047279735.1  serine/threonine-protein kinase WNK2 isoform X49

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    105350754..105487952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)