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WNK2 WNK lysine deficient protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 65268, updated on 1-Jun-2020

Summary

Official Symbol
WNK2provided by HGNC
Official Full Name
WNK lysine deficient protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:14542
See related
Ensembl:ENSG00000165238 MIM:606249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13
Summary
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in heart (RPKM 6.5), colon (RPKM 6.3) and 18 other tissues See more
Orthologs

Genomic context

See WNK2 in Genome Data Viewer
Location:
9q22.31
Exon count:
38
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (93184156..93327581)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95946437..96082854)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family member 19 Neighboring gene ninjurin 1 Neighboring gene chromosome 9 open reading frame 129 Neighboring gene RNA, U6 small nuclear 829, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1760

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chloride channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of potassium ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of sodium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase WNK2
Names
antigen NY-CO-43
mitogen-activated protein kinase kinase kinase
protein kinase lysine-deficient 2
protein kinase with no lysine 2
serologically defined colon cancer antigen 43
NP_001269323.1
NP_006639.3
XP_005252194.1
XP_005252197.1
XP_005252198.1
XP_005252201.1
XP_011517228.1
XP_011517229.1
XP_011517230.1
XP_011517231.1
XP_011517232.1
XP_011517233.1
XP_011517234.1
XP_011517237.1
XP_011517238.1
XP_011517239.1
XP_011517241.1
XP_011517242.1
XP_016870534.1
XP_016870535.1
XP_016870536.1
XP_016870537.1
XP_016870538.1
XP_016870539.1
XP_016870540.1
XP_016870541.1
XP_016870542.1
XP_016870543.1
XP_016870544.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282394.1NP_001269323.1  serine/threonine-protein kinase WNK2 isoform 1

    See identical proteins and their annotated locations for NP_001269323.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AJ242724, AL583839, HY151846
    Consensus CDS
    CCDS75858.1
    UniProtKB/Swiss-Prot
    Q9Y3S1
    Related
    ENSP00000297954.4, ENST00000297954.8
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. NM_006648.3NP_006639.3  serine/threonine-protein kinase WNK2 isoform 2

    See identical proteins and their annotated locations for NP_006639.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL354991, AL390760, AL583839
    UniProtKB/TrEMBL
    F8W9F9
    Related
    ENSP00000378860.2, ENST00000395477.6
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    93184156..93327581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252141.2XP_005252198.1  serine/threonine-protein kinase WNK2 isoform X16

    See identical proteins and their annotated locations for XP_005252198.1

    UniProtKB/TrEMBL
    F8W9F9
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. XM_011518926.2XP_011517228.1  serine/threonine-protein kinase WNK2 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  3. XM_011518932.2XP_011517234.1  serine/threonine-protein kinase WNK2 isoform X10

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  4. XM_005252137.3XP_005252194.1  serine/threonine-protein kinase WNK2 isoform X5

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  5. XM_005252140.2XP_005252197.1  serine/threonine-protein kinase WNK2 isoform X15

    UniProtKB/Swiss-Prot
    Q9Y3S1
    Related
    ENSP00000415038.1, ENST00000432730.5
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  6. XM_011518929.2XP_011517231.1  serine/threonine-protein kinase WNK2 isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  7. XM_017015049.1XP_016870538.1  serine/threonine-protein kinase WNK2 isoform X13

  8. XM_011518931.2XP_011517233.1  serine/threonine-protein kinase WNK2 isoform X9

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  9. XM_011518935.2XP_011517237.1  serine/threonine-protein kinase WNK2 isoform X20

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  10. XM_017015054.1XP_016870543.1  serine/threonine-protein kinase WNK2 isoform X23

  11. XM_011518936.2XP_011517238.1  serine/threonine-protein kinase WNK2 isoform X21

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  12. XM_011518928.2XP_011517230.1  serine/threonine-protein kinase WNK2 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  13. XM_017015047.1XP_016870536.1  serine/threonine-protein kinase WNK2 isoform X11

  14. XM_017015052.1XP_016870541.1  serine/threonine-protein kinase WNK2 isoform X18

  15. XM_011518927.2XP_011517229.1  serine/threonine-protein kinase WNK2 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  16. XM_017015045.1XP_016870534.1  serine/threonine-protein kinase WNK2 isoform X6

  17. XM_017015050.1XP_016870539.1  serine/threonine-protein kinase WNK2 isoform X14

  18. XM_017015055.1XP_016870544.1  serine/threonine-protein kinase WNK2 isoform X24

  19. XM_017015048.1XP_016870537.1  serine/threonine-protein kinase WNK2 isoform X12

  20. XM_017015053.1XP_016870542.1  serine/threonine-protein kinase WNK2 isoform X19

  21. XM_011518930.2XP_011517232.1  serine/threonine-protein kinase WNK2 isoform X7

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  22. XM_017015051.1XP_016870540.1  serine/threonine-protein kinase WNK2 isoform X17

  23. XM_017015046.1XP_016870535.1  serine/threonine-protein kinase WNK2 isoform X8

  24. XM_005252144.2XP_005252201.1  serine/threonine-protein kinase WNK2 isoform X22

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  25. XM_011518937.3XP_011517239.1  serine/threonine-protein kinase WNK2 isoform X25

    Conserved Domains (3) summary
    smart00220
    Location:13238
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:259296
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:11243
    PKc_like; Protein Kinases, catalytic domain
  26. XM_011518940.2XP_011517242.1  serine/threonine-protein kinase WNK2 isoform X26

    See identical proteins and their annotated locations for XP_011517242.1

    Conserved Domains (3) summary
    smart00220
    Location:1209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:230267
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:1214
    PKc_like; Protein Kinases, catalytic domain
  27. XM_011518939.2XP_011517241.1  serine/threonine-protein kinase WNK2 isoform X26

    See identical proteins and their annotated locations for XP_011517241.1

    Conserved Domains (3) summary
    smart00220
    Location:1209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:230267
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:1214
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_002956804.1 RNA Sequence

  2. XR_001746367.1 RNA Sequence

  3. XR_002956803.1 RNA Sequence

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