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WNK3 WNK lysine deficient protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 65267, updated on 5-Sep-2021

Summary

Official Symbol
WNK3provided by HGNC
Official Full Name
WNK lysine deficient protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:14543
See related
Ensembl:ENSG00000196632 MIM:300358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKWNK3
Summary
This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Biased expression in testis (RPKM 7.2), brain (RPKM 1.1) and 5 other tissues See more
Orthologs
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Genomic context

See WNK3 in Genome Data Viewer
Location:
Xp11.22
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (54192823..54358695, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (54219256..54384479, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 8 Neighboring gene family with sequence similarity 120C Neighboring gene ribosomal protein L37 pseudogene 24 Neighboring gene ribosomal protein L7a pseudogene 71 Neighboring gene RNA, U6 small nuclear 434, pseudogene Neighboring gene TSR2 ribosome maturation factor Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene G protein nucleolar 3 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30437, FLJ42662, KIAA1566

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chloride channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of cell volume homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell volume homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maintenance of blood-brain barrier ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of osmosensory signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of cation transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase WNK3
Names
protein kinase with no lysine 3
NP_001002838.1
NP_065973.2
XP_006724656.1
XP_011529104.1
XP_016885230.1
XP_016885231.1
XP_016885232.1
XP_016885233.1
XP_016885234.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021259.2 RefSeqGene

    Range
    5001..170183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002838.4NP_001002838.1  serine/threonine-protein kinase WNK3 isoform 2

    See identical proteins and their annotated locations for NP_001002838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AJ409088, AL591766, AY352048, R44257, Z84469
    Consensus CDS
    CCDS35302.1
    UniProtKB/Swiss-Prot
    Q9BYP7
    Related
    ENSP00000364312.3, ENST00000375169.7
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. NM_001395166.1NP_001382095.1  serine/threonine-protein kinase WNK3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL049793, AL591766, Z84469
  3. NM_020922.5NP_065973.2  serine/threonine-protein kinase WNK3 isoform 1

    See identical proteins and their annotated locations for NP_065973.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL591766, AY352048, R44257, Z84469
    Consensus CDS
    CCDS14357.1
    UniProtKB/Swiss-Prot
    Q9BYP7
    Related
    ENSP00000346667.2, ENST00000354646.6
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    54192823..54358695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029744.1XP_016885233.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYP7
    Related
    ENSP00000364301.2, ENST00000375159.6
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. XM_017029743.1XP_016885232.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYP7
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  3. XM_017029741.1XP_016885230.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYP7
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  4. XM_017029742.1XP_016885231.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYP7
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  5. XM_006724593.3XP_006724656.1  serine/threonine-protein kinase WNK3 isoform X4

    UniProtKB/Swiss-Prot
    Q9BYP7
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  6. XM_011530802.2XP_011529104.1  serine/threonine-protein kinase WNK3 isoform X3

    See identical proteins and their annotated locations for XP_011529104.1

    UniProtKB/Swiss-Prot
    Q9BYP7
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  7. XM_017029745.1XP_016885234.1  serine/threonine-protein kinase WNK3 isoform X2

    UniProtKB/Swiss-Prot
    Q9BYP7
    Related
    ENSP00000481888.1, ENST00000620763.1
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