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UBE2Z ubiquitin conjugating enzyme E2 Z [ Homo sapiens (human) ]

Gene ID: 65264, updated on 18-Sep-2024

Summary

Official Symbol
UBE2Zprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Zprovided by HGNC
Primary source
HGNC:HGNC:25847
See related
Ensembl:ENSG00000159202 MIM:611362; AllianceGenome:HGNC:25847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USE1; HOYS7
Summary
This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in thyroid (RPKM 33.3), brain (RPKM 25.6) and 25 other tissues See more
Orthologs
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Genomic context

See UBE2Z in Genome Data Viewer
Location:
17q21.32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48908407..48929056)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (49772123..49792776)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46985769..47006418)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12345 Neighboring gene ATP synthase membrane subunit c locus 1 Neighboring gene ribosomal protein L37 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12348 Neighboring gene SNF8 subunit of ESCRT-II Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8664 Neighboring gene RNA, U1 small nuclear 42, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin-conjugating enzyme E2Z (UBE2Z) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ13855

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 Z
Names
E2 ubiquitin-conjugating enzyme Z
UBA6-specific enzyme E2
uba6-specific E2 conjugating enzyme 1
ubiquitin carrier protein Z
ubiquitin conjugating enzyme E2Z
ubiquitin-protein ligase Z
NP_075567.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023079.5NP_075567.2  ubiquitin-conjugating enzyme E2 Z

    See identical proteins and their annotated locations for NP_075567.2

    Status: VALIDATED

    Source sequence(s)
    AC091133, AK122770, AL713782, BC015890
    Consensus CDS
    CCDS11540.2
    UniProtKB/Swiss-Prot
    A6N8M6, A6NC60, Q7L354, Q8TCM4, Q9H832, Q9H893
    Related
    ENSP00000354201.5, ENST00000360943.10
    Conserved Domains (1) summary
    cd00195
    Location:103221
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    48908407..48929056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    49772123..49792776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)