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UBE2Z ubiquitin conjugating enzyme E2 Z [ Homo sapiens (human) ]

Gene ID: 65264, updated on 24-Nov-2020

Summary

Official Symbol
UBE2Zprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Zprovided by HGNC
Primary source
HGNC:HGNC:25847
See related
Ensembl:ENSG00000159202 MIM:611362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USE1; HOYS7
Summary
This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in thyroid (RPKM 33.3), brain (RPKM 25.6) and 25 other tissues See more
Orthologs

Genomic context

See UBE2Z in Genome Data Viewer
Location:
17q21.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (48908407..48929056)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46985731..47006422)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371814 Neighboring gene ATP synthase membrane subunit c locus 1 Neighboring gene ribosomal protein L37 pseudogene Neighboring gene SNF8 subunit of ESCRT-II Neighboring gene RNA, U1 small nuclear 42, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin-conjugating enzyme E2Z (UBE2Z) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13855

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 Z
Names
E2 ubiquitin-conjugating enzyme Z
UBA6-specific enzyme E2
uba6-specific E2 conjugating enzyme 1
ubiquitin carrier protein Z
ubiquitin conjugating enzyme E2Z
ubiquitin-protein ligase Z
NP_075567.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023079.5NP_075567.2  ubiquitin-conjugating enzyme E2 Z

    See identical proteins and their annotated locations for NP_075567.2

    Status: VALIDATED

    Source sequence(s)
    AC091133, AK122770, AL713782, BC015890
    Consensus CDS
    CCDS11540.2
    UniProtKB/Swiss-Prot
    Q9H832
    Related
    ENSP00000354201.5, ENST00000360943.10
    Conserved Domains (1) summary
    cd00195
    Location:103221
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    48908407..48929056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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