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Atp5f1a ATP synthase F1 subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 65262, updated on 13-Oct-2022

Summary

Official Symbol
Atp5f1aprovided by RGD
Official Full Name
ATP synthase F1 subunit alphaprovided by RGD
Primary source
RGD:619993
See related
Ensembl:ENSRNOG00000017032 AllianceGenome:RGD:619993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5a1
Summary
Enables ADP binding activity; ATP binding activity; and protease binding activity. Contributes to ATP hydrolysis activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to nitric oxide; and response to muscle activity. Located in several cellular components, including cell surface; membrane raft; and mitochondrial inner membrane. Part of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1). Used to study non-alcoholic fatty liver disease and pulmonary hypertension. Biomarker of Alzheimer's disease and hypertension. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22 and mitochondrial complex V (ATP synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 13827.6), Muscle (RPKM 9553.0) and 8 other tissues See more
Orthologs
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Genomic context

See Atp5f1a in Genome Data Viewer
Location:
18q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (71292406..71300342)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (74156553..74164490)

Chromosome 18 - NC_051353.1Genomic Context describing neighboring genes Neighboring gene similar to hypothetical protein Neighboring gene small nucleolar RNA SNORA17 Neighboring gene HAUS augmin-like complex, subunit 1 Neighboring gene proline-serine-threonine phosphatase-interacting protein 2 Neighboring gene ectopic P-granules 5 autophagy tethering factor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MHC class I protein binding IEA
Inferred from Electronic Annotation
more info
 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables angiostatin binding IEA
Inferred from Electronic Annotation
more info
 
enables angiostatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
 
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
 
enables proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ATP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to nitric oxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proton motive force-driven ATP synthesis ISO
Inferred from Sequence Orthology
more info
 
involved_in proton motive force-driven mitochondrial ATP synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to muscle activity IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial proton-transporting ATP synthase complex IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial proton-transporting ATP synthase, catalytic core IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IDA
Inferred from Direct Assay
more info
PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP synthase subunit alpha, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
mitochondrial H+-ATP synthase alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023093.1NP_075581.1  ATP synthase subunit alpha, mitochondrial precursor

    See identical proteins and their annotated locations for NP_075581.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061830
    UniProtKB/Swiss-Prot
    P15999, Q6P753
    Related
    ENSRNOP00000022892.4, ENSRNOT00000022892.6
    Conserved Domains (1) summary
    PRK09281
    Location:49553
    PRK09281; F0F1 ATP synthase subunit alpha; Validated

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051353.1 Reference mRatBN7.2 Primary Assembly

    Range
    71292406..71300342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)