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COA7 cytochrome c oxidase assembly factor 7 [ Homo sapiens (human) ]

Gene ID: 65260, updated on 7-Apr-2025

Summary

Official Symbol
COA7provided by HGNC
Official Full Name
cytochrome c oxidase assembly factor 7provided by HGNC
Primary source
HGNC:HGNC:25716
See related
Ensembl:ENSG00000162377 MIM:615623; AllianceGenome:HGNC:25716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RESA1; SCAN3; SELRC1; C1orf163
Summary
Involved in respiratory chain complex IV assembly. Located in mitochondrion and nucleoplasm. Is active in mitochondrial intermembrane space. Implicated in spinocerebellar ataxia with axonal neuropathy type 3. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in brain (RPKM 6.1), colon (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See COA7 in Genome Data Viewer
Location:
1p32.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52684449..52698347, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52566007..52579888, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53150121..53164019, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 7 Neighboring gene uncharacterized LOC124904178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1034 Neighboring gene shisa like 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1035 Neighboring gene Sharpr-MPRA regulatory region 2435 Neighboring gene Sharpr-MPRA regulatory region 753 Neighboring gene Sharpr-MPRA regulatory region 13275 Neighboring gene MPRA-validated peak230 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1036 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53168550-53169091 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53169092-53169632 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 62, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Sel1 repeat containing 1 (SELRC1; C1orf163) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
cytochrome c oxidase assembly factor 7
Names
Sel1 repeat containing 1
beta-lactamase hcp-like protein
cytochrome c oxidase assembly factor 7 (putative)
epididymis secretory sperm binding protein
hcp beta-lactamase-like protein C1orf163
respiratory chain assembly 1
respiratory chain assembly factor 1
sel1 repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023077.3NP_075565.2  cytochrome c oxidase assembly factor 7

    See identical proteins and their annotated locations for NP_075565.2

    Status: VALIDATED

    Source sequence(s)
    AC099784, AK022501, BC015313
    Consensus CDS
    CCDS570.1
    UniProtKB/Swiss-Prot
    Q0P6I7, Q96BR5, Q9H9Z9
    UniProtKB/TrEMBL
    A0A384MTZ4
    Related
    ENSP00000360593.3, ENST00000371538.5
    Conserved Domains (2) summary
    COG0790
    Location:31218
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:5080
    SLR; SLR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    52684449..52698347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    52566007..52579888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)