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MPPE1 metallophosphoesterase 1 [ Homo sapiens (human) ]

Gene ID: 65258, updated on 22-Sep-2022

Summary

Official Symbol
MPPE1provided by HGNC
Official Full Name
metallophosphoesterase 1provided by HGNC
Primary source
HGNC:HGNC:15988
See related
Ensembl:ENSG00000154889 MIM:611900; AllianceGenome:HGNC:15988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cdc1; PGAP5
Summary
Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 13.2), prostate (RPKM 8.5) and 25 other tissues See more
Orthologs
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Genomic context

See MPPE1 in Genome Data Viewer
Location:
18p11.21
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (11882622..11908317, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (12045331..12071022, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (11882621..11908316, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha L Neighboring gene uncharacterized LOC124904251 Neighboring gene uncharacterized LOC124904252 Neighboring gene uncharacterized LOC101927511 Neighboring gene CRISPRi-validated cis-regulatory element chr18.397 Neighboring gene inositol monophosphatase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GPI anchor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GPI-mannose ethanolamine phosphate phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in cis-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum exit site ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
metallophosphoesterase 1
Names
metallo phosphoesterase
post-GPI attachment to proteins 5
post-GPI attachment to proteins factor 5
NP_001229833.1
NP_001306083.1
NP_001317492.1
NP_075563.3
XP_006722403.1
XP_006722404.1
XP_006722405.1
XP_006722406.1
XP_006722408.1
XP_006722409.1
XP_006722411.1
XP_011524033.1
XP_011524034.1
XP_016881411.1
XP_016881412.1
XP_016881413.1
XP_016881414.1
XP_016881416.1
XP_016881417.1
XP_016881418.1
XP_016881419.1
XP_016881420.1
XP_047293699.1
XP_047293700.1
XP_047293701.1
XP_047293702.1
XP_047293703.1
XP_047293704.1
XP_047293705.1
XP_047293706.1
XP_047293707.1
XP_047293708.1
XP_047293709.1
XP_047293710.1
XP_047293711.1
XP_047293712.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242904.2NP_001229833.1  metallophosphoesterase 1 isoform 2

    See identical proteins and their annotated locations for NP_001229833.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5'UTR and lacks two consecutive exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Both variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AL833636, AP001269, AW663162, BC002877, CR738004, DB035278
    Consensus CDS
    CCDS56054.1
    UniProtKB/Swiss-Prot
    Q53F39
    Related
    ENSP00000311200.9, ENST00000309976.13
    Conserved Domains (1) summary
    cd08165
    Location:73266
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
  2. NM_001319154.2NP_001306083.1  metallophosphoesterase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two consecutive exons in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Both variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AL536593, AL833636, AP001269
    Consensus CDS
    CCDS56054.1
    UniProtKB/Swiss-Prot
    Q53F39
    Related
    ENSP00000327257.6, ENST00000317235.11
    Conserved Domains (1) summary
    cd08165
    Location:73266
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
  3. NM_001330563.2NP_001317492.1  metallophosphoesterase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833636, AP001269
    Consensus CDS
    CCDS82242.1
    UniProtKB/TrEMBL
    A0A0A0MR93
    Related
    ENSP00000339423.7, ENST00000344987.11
    Conserved Domains (2) summary
    cd08165
    Location:73307
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70283
    Metallophos; Calcineurin-like phosphoesterase
  4. NM_023075.6NP_075563.3  metallophosphoesterase 1 isoform 1

    See identical proteins and their annotated locations for NP_075563.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF363484, AL833636, AP001269, AW663162, BC002877, DB035278
    Consensus CDS
    CCDS11853.1
    UniProtKB/Swiss-Prot
    Q53F39, Q9HAI4
    Related
    ENSP00000465894.1, ENST00000588072.6
    Conserved Domains (2) summary
    cd08165
    Location:73329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70305
    Metallophos; Calcineurin-like phosphoesterase

RNA

  1. NR_040241.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate penultimate exon. This results in a frameshift and premature stop codon which renders the transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AF289560, AL833636, AP001269, AW663162, BC073994
  2. NR_040242.4 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes 2 alternate exons and represents use of an alternate splice acceptor site, compared to variant 1. These differences result in a frameshift and premature stop codon which renders the transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AK021647, AK054639, AL833636, AP001269, AW663162, BC073994, DB035278
  3. NR_040243.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate penultimate exon compared to variant 1. This results in a frameshift and premature stop codon which renders the transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AL833636, AP001269, AW663162, BC002877, BC073994, CR738004, DB035278

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    11882622..11908317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025929.3XP_016881418.1  metallophosphoesterase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MR93
    Conserved Domains (2) summary
    cd08165
    Location:73307
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70283
    Metallophos; Calcineurin-like phosphoesterase
  2. XM_006722346.4XP_006722409.1  metallophosphoesterase 1 isoform X2

    See identical proteins and their annotated locations for XP_006722409.1

    UniProtKB/Swiss-Prot
    Q53F39, Q9HAI4
    Conserved Domains (2) summary
    cd08165
    Location:73329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70305
    Metallophos; Calcineurin-like phosphoesterase
  3. XM_006722345.5XP_006722408.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_006722408.1

    Conserved Domains (2) summary
    cd08165
    Location:73330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70306
    Metallophos; Calcineurin-like phosphoesterase
  4. XM_006722340.4XP_006722403.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_006722403.1

    Conserved Domains (2) summary
    cd08165
    Location:73330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70306
    Metallophos; Calcineurin-like phosphoesterase
  5. XM_017025927.3XP_016881416.1  metallophosphoesterase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MR93
    Conserved Domains (2) summary
    cd08165
    Location:73307
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70283
    Metallophos; Calcineurin-like phosphoesterase
  6. XM_017025924.3XP_016881413.1  metallophosphoesterase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q53F39, Q9HAI4
    Conserved Domains (2) summary
    cd08165
    Location:73329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70305
    Metallophos; Calcineurin-like phosphoesterase
  7. XM_006722342.5XP_006722405.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_006722405.1

    Conserved Domains (2) summary
    cd08165
    Location:73330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70306
    Metallophos; Calcineurin-like phosphoesterase
  8. XM_017025928.2XP_016881417.1  metallophosphoesterase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MR93
    Conserved Domains (2) summary
    cd08165
    Location:73307
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70283
    Metallophos; Calcineurin-like phosphoesterase
  9. XM_017025925.2XP_016881414.1  metallophosphoesterase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q53F39, Q9HAI4
    Conserved Domains (2) summary
    cd08165
    Location:73329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70305
    Metallophos; Calcineurin-like phosphoesterase
  10. XM_006722343.4XP_006722406.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_006722406.1

    Conserved Domains (2) summary
    cd08165
    Location:73330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70306
    Metallophos; Calcineurin-like phosphoesterase
  11. XM_047437753.1XP_047293709.1  metallophosphoesterase 1 isoform X6

  12. XM_047437748.1XP_047293704.1  metallophosphoesterase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MR93
  13. XM_017025922.3XP_016881411.1  metallophosphoesterase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q53F39, Q9HAI4
    Conserved Domains (2) summary
    cd08165
    Location:73329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70305
    Metallophos; Calcineurin-like phosphoesterase
  14. XM_006722341.5XP_006722404.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_006722404.1

    Conserved Domains (2) summary
    cd08165
    Location:73330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70306
    Metallophos; Calcineurin-like phosphoesterase
  15. XM_047437746.1XP_047293702.1  metallophosphoesterase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9HAI4
  16. XM_047437745.1XP_047293701.1  metallophosphoesterase 1 isoform X1

  17. XM_047437754.1XP_047293710.1  metallophosphoesterase 1 isoform X6

  18. XM_017025923.3XP_016881412.1  metallophosphoesterase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q53F39, Q9HAI4
    Conserved Domains (2) summary
    cd08165
    Location:73329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70305
    Metallophos; Calcineurin-like phosphoesterase
  19. XM_011525731.4XP_011524033.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_011524033.1

    Conserved Domains (2) summary
    cd08165
    Location:73330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70306
    Metallophos; Calcineurin-like phosphoesterase
  20. XM_047437744.1XP_047293700.1  metallophosphoesterase 1 isoform X1

  21. XM_047437749.1XP_047293705.1  metallophosphoesterase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MR93
  22. XM_047437747.1XP_047293703.1  metallophosphoesterase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9HAI4
  23. XM_047437743.1XP_047293699.1  metallophosphoesterase 1 isoform X1

  24. XM_017025930.3XP_016881419.1  metallophosphoesterase 1 isoform X5

    UniProtKB/Swiss-Prot
    Q53F39
    Related
    ENSP00000468606.1, ENST00000592977.5
    Conserved Domains (2) summary
    cd08165
    Location:73329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70305
    Metallophos; Calcineurin-like phosphoesterase
  25. XM_047437750.1XP_047293706.1  metallophosphoesterase 1 isoform X5

    Related
    ENSP00000433950.1, ENST00000496196.5
  26. XM_011525732.3XP_011524034.1  metallophosphoesterase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q53F39
    Conserved Domains (2) summary
    cd08165
    Location:73330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70306
    Metallophos; Calcineurin-like phosphoesterase
  27. XM_047437752.1XP_047293708.1  metallophosphoesterase 1 isoform X5

  28. XM_047437756.1XP_047293712.1  metallophosphoesterase 1 isoform X10

  29. XM_047437755.1XP_047293711.1  metallophosphoesterase 1 isoform X7

  30. XM_047437751.1XP_047293707.1  metallophosphoesterase 1 isoform X5

  31. XM_006722348.3XP_006722411.1  metallophosphoesterase 1 isoform X9

    Conserved Domains (2) summary
    cd08165
    Location:73178
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:70194
    Metallophos; Calcineurin-like phosphoesterase
  32. XM_017025931.2XP_016881420.1  metallophosphoesterase 1 isoform X8

    Related
    ENST00000589731.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    12045331..12071022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138608.2: Suppressed sequence

    Description
    NM_138608.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.