U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZSWIM4 zinc finger SWIM-type containing 4 [ Homo sapiens (human) ]

Gene ID: 65249, updated on 4-Nov-2022

Summary

Official Symbol
ZSWIM4provided by HGNC
Official Full Name
zinc finger SWIM-type containing 4provided by HGNC
Primary source
HGNC:HGNC:25704
See related
Ensembl:ENSG00000132003 AllianceGenome:HGNC:25704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable zinc ion binding activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 2.3), lung (RPKM 2.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZSWIM4 in Genome Data Viewer
Location:
19p13.13-p13.12
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (13795443..13832254)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13921625..13958384)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13906257..13943068)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene methylthioribose-1-phosphate isomerase 1 Neighboring gene chromosome 19 open reading frame 53 Neighboring gene uncharacterized LOC107985334 Neighboring gene RNA, 7SL, cytoplasmic 619, pseudogene Neighboring gene miR-23a/27a/24-2 cluster host gene Neighboring gene microRNA 24-2 Neighboring gene microRNA 27a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger, SWIM-type containing 4 (ZSWIM4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger SWIM domain-containing protein 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367834.3NP_001354763.1  zinc finger SWIM domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Consensus CDS
    CCDS92534.1
    UniProtKB/TrEMBL
    K7ERJ6
    Related
    ENSP00000468285.2, ENST00000590508.6
  2. NM_023072.3NP_075560.2  zinc finger SWIM domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_075560.2

    Status: VALIDATED

    Source sequence(s)
    AC020916, AK022283, AK024452, BG764264
    Consensus CDS
    CCDS32924.1
    UniProtKB/Swiss-Prot
    Q9H7M6
    UniProtKB/TrEMBL
    Q9HA55
    Related
    ENSP00000254323.2, ENST00000254323.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    13795443..13832254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027153.2XP_016882642.1  zinc finger SWIM domain-containing protein 4 isoform X1

  2. XM_047439236.1XP_047295192.1  zinc finger SWIM domain-containing protein 4 isoform X6

  3. XM_017027155.2XP_016882644.1  zinc finger SWIM domain-containing protein 4 isoform X3

  4. XM_047439235.1XP_047295191.1  zinc finger SWIM domain-containing protein 4 isoform X4

  5. XM_017027154.2XP_016882643.1  zinc finger SWIM domain-containing protein 4 isoform X2

  6. XM_017027156.2XP_016882645.1  zinc finger SWIM domain-containing protein 4 isoform X8

  7. XM_047439237.1XP_047295193.1  zinc finger SWIM domain-containing protein 4 isoform X7

  8. XM_017027157.2XP_016882646.1  zinc finger SWIM domain-containing protein 4 isoform X9

  9. XM_024451657.2XP_024307425.1  zinc finger SWIM domain-containing protein 4 isoform X5

RNA

  1. XR_007066949.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160022.1 Reference GRCh38.p14 PATCHES

    Range
    7284..44095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    13921625..13958384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)