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Asb1 ankyrin repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

Gene ID: 65247, updated on 5-Aug-2018

Summary

Official Symbol
Asb1provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 1provided by MGI
Primary source
MGI:MGI:1929735
See related
Ensembl:ENSMUSG00000026311 Vega:OTTMUSG00000048498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI426616; AI851378; mKIAA1146; 1700029O08Rik; 1700054C17Rik
Expression
Ubiquitous expression in testis adult (RPKM 17.6), liver E14 (RPKM 5.4) and 23 other tissues See more
Orthologs

Genomic context

See Asb1 in Genome Data Viewer
Location:
1 D; 1 46.19 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (91539455..91559590)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (93437142..93456167)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene nucleolar complex associated 3 homolog pseudogene Neighboring gene TRAF3 interacting protein 1 Neighboring gene predicted gene 28380 Neighboring gene twist basic helix-loop-helix transcription factor 2 Neighboring gene predicted gene, 46117

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
male genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 1
Names
ASB-1
ankyrin repeat and SOCS box-containing protein 1
ankyrin repeat-containing SOCS box protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039126.2NP_001034215.1  ankyrin repeat and SOCS box protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC109199, AK153774, BY231875
    Consensus CDS
    CCDS35665.1
    UniProtKB/Swiss-Prot
    Q9WV74
    UniProtKB/TrEMBL
    Q3U5A0
    Related
    ENSMUSP00000084054.5, OTTMUSP00000067671, ENSMUST00000086843.10, OTTMUST00000124308
    Conserved Domains (5) summary
    cd00204
    Location:80213
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:295336
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:83174
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4099
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:80109
    ANK; ANK repeat [structural motif]
  2. NM_023046.4NP_075533.3  ankyrin repeat and SOCS box protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC109199, AK153774, BU938650
    Consensus CDS
    CCDS35666.1
    UniProtKB/TrEMBL
    G3X9J5, Q3U5A0
    Related
    ENSMUSP00000140731.1, OTTMUSP00000067676, ENSMUST00000188879.1, OTTMUST00000124315
    Conserved Domains (5) summary
    cd00204
    Location:72205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:287328
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:75166
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3291
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:72101
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    91539455..91559590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529790.3XP_006529853.1  ankyrin repeat and SOCS box protein 1 isoform X2

    Related
    ENSMUSP00000140281.1, OTTMUSP00000067673, ENSMUST00000190484.6, OTTMUST00000124312
    Conserved Domains (4) summary
    cd00204
    Location:40166
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:194235
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:42166
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:3972
    ANK; ANK repeat [structural motif]
  2. XM_006529789.1XP_006529852.1  ankyrin repeat and SOCS box protein 1 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:76209
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:291332
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:79170
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3695
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:76105
    ANK; ANK repeat [structural motif]
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