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SLC5A2 solute carrier family 5 member 2 [ Homo sapiens (human) ]

Gene ID: 6524, updated on 6-Nov-2022

Summary

Official Symbol
SLC5A2provided by HGNC
Official Full Name
solute carrier family 5 member 2provided by HGNC
Primary source
HGNC:HGNC:11037
See related
Ensembl:ENSG00000140675 MIM:182381; AllianceGenome:HGNC:11037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGLT2
Summary
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
Expression
Broad expression in kidney (RPKM 31.7), ovary (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

See SLC5A2 in Genome Data Viewer
Location:
16p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31483123..31490769)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31870510..31878162)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31494444..31502090)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 5 Neighboring gene transforming growth factor beta 1 induced transcript 1 Neighboring gene RUS family member 1 Neighboring gene alpha hemoglobin stabilizing protein Neighboring gene long intergenic non-protein coding RNA 2190 Neighboring gene vomeronasal 1 receptor 64 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in alpha-glucoside transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in glucose import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in renal glucose absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sodium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/glucose cotransporter 2
Names
Na(+)/glucose cotransporter 2
low affinity sodium-glucose cotransporter
solute carrier family 5 (sodium/glucose cotransporter), member 2
solute carrier family 5 (sodium/glucose transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012892.1 RefSeqGene

    Range
    5006..12652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003041.4NP_003032.1  sodium/glucose cotransporter 2

    See identical proteins and their annotated locations for NP_003032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer, protein-coding transcript.
    Source sequence(s)
    AI222550, M95549
    Consensus CDS
    CCDS10714.1
    UniProtKB/Swiss-Prot
    A2RRD2, P31639
    Related
    ENSP00000327943.3, ENST00000330498.4
    Conserved Domains (1) summary
    cd11487
    Location:24672
    SLC5sbd_SGLT2; Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain

RNA

  1. NR_130783.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI222550, BC131542

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31483123..31490769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721072.5XP_006721135.3  sodium/glucose cotransporter 2 isoform X1

    UniProtKB/TrEMBL
    Q8WY15
  2. XM_024450402.2XP_024306170.2  sodium/glucose cotransporter 2 isoform X2

    Related
    ENSP00000410601.2, ENST00000419665.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31870510..31878162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)