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SLC5A1 solute carrier family 5 member 1 [ Homo sapiens (human) ]

Gene ID: 6523, updated on 25-Nov-2021

Summary

Official Symbol
SLC5A1provided by HGNC
Official Full Name
solute carrier family 5 member 1provided by HGNC
Primary source
HGNC:HGNC:11036
See related
Ensembl:ENSG00000100170 MIM:182380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAGT; SGLT1; D22S675
Summary
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Biased expression in duodenum (RPKM 262.7), small intestine (RPKM 154.2) and 1 other tissue See more
Orthologs
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Genomic context

See SLC5A1 in Genome Data Viewer
Location:
22q12.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (32043050..32113029)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (32439248..32509016)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2558 Neighboring gene RNA, 7SL, cytoplasmic 305, pseudogene Neighboring gene ribosomal protein S17 pseudogene 16 Neighboring gene uncharacterized LOC105373000 Neighboring gene AP1B1 pseudogene 1 Neighboring gene AP1B1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces Na-D-glucose symporter (SGLT-1) mis-sorting and inhibits glucose uptake in human enterocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in alpha-glucoside transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in alpha-glucoside transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in alpha-glucoside transport ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in galactose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose import across plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal hexose absorption TAS
Traceable Author Statement
more info
 
involved_in myo-inositol transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pentose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to inorganic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transepithelial water transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transport across blood-brain barrier IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in intracellular organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/glucose cotransporter 1
Names
Na+/glucose cotransporter 1
high affinity sodium-glucose cotransporter
solute carrier family 5 (sodium/glucose cotransporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017045.1 RefSeqGene

    Range
    5230..74998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000343.4NP_000334.1  sodium/glucose cotransporter 1 isoform 1

    See identical proteins and their annotated locations for NP_000334.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK312948, DQ656053, Z83839
    Consensus CDS
    CCDS13902.1
    UniProtKB/Swiss-Prot
    P13866
    Related
    ENSP00000266088.4, ENST00000266088.9
    Conserved Domains (1) summary
    cd11486
    Location:27664
    SLC5sbd_SGLT1; Na(+)/glucose cotransporter SGLT1;solute binding domain
  2. NM_001256314.2NP_001243243.1  sodium/glucose cotransporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001243243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK297665, M24847, Z74021, Z83839
    Consensus CDS
    CCDS58805.1
    UniProtKB/Swiss-Prot
    P13866
    Related
    ENSP00000444898.1, ENST00000543737.2
    Conserved Domains (1) summary
    cl00456
    Location:1537
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    32043050..32113029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530331.1XP_011528633.1  sodium/glucose cotransporter 1 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:27427
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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